Search Results - fred+kramer

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Analysis of Immune Repertoire with Fluorogenic Probes

Rapid analysis of T cells for the diagnosis of diseases in which the T cell repertoire is altered. Cells are distributed in aqueous droplets and their T cell receptor mRNAs are amplified in presence of “sloppy” molecular beacons. The melt profiles of molecular beacons in thousands of droplets reveals the T cell repertoire of...

Published: 2/20/2026 | Inventor(s): Sanjay Tyagi, Fred Kramer, Salvatore Marras, Ryan Dikdan, Stan Kwang

Keywords(s):

Category(s): Technology Classifications > Diagnostics

SuperSelective PCR Primers

Structure of a SuperSelective primer for the detection and quantitation of rare mutant sequences in the presence of 1,000,000 wild-type sequences; and a demonstration that the number of amplification cycles required to generate a signal above background is inversely linearly proportional to the logarithm of the number of mutant molecules in the original...

Published: 2/20/2026 | Inventor(s): Salvatore Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred Kramer

Keywords(s): Anti-cancer, Sensors & Probes

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics