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SuperSelective PCR Primers
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Structure of a SuperSelective primer for the detection and quantitation of rare mutant sequences in the presence of 1,000,000 wild-type sequences; and a demonstration that the number of amplification cycles required to generate a signal above background is inversely linearly proportional to the logarithm of the number of mutant molecules in the original...
Published: 10/9/2024
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Inventor(s): Salvatore Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred Kramer
Keywords(s): Anti-cancer, Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
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Gel-Tethered Molecular Beacons for Detection of Microbes
Invention Summary:
Pathogen detection and characterization is a critical first step in the course of care for individuals suffering from these infectious diseases, and the speed by which this pathogen detection occurs can make all the difference between life or death for many patients. Currently, the gold standard for microbe quantification is either...
Published: 12/4/2024
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Inventor(s): Salvatore Marras, Xiaoguang Dai, Matthew Libera
Keywords(s): Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Rapid Diagnostics of Tick-borne Diseases
Invention Summary:
Tick-borne diseases are a major health problem in the United States. Among them, Lyme disease due to the Borrelia spp., Anaplasmosis due to Anaplasma spp., and Babesiosis caused by Babesia spp., account for a large number of cases occurring throughout the country. Although treatment is readily available to combat these pathogens,...
Published: 12/4/2024
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Inventor(s): Nikhat Parveen, Salvatore Marras
Keywords(s): Disease Animal Models, Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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High-fidelity amplified FISH (amp-FISH) for sensitive and specific in situ detection of RNA
amp-FISH probes can distinguish single-nucleotide variations within single mRNA molecules and produces amplified signals in situ for both mutant and wild-type variants, each in a distinct color.
Invention Summary:
Fluorescence in situ hybridization (FISH) is used in clinical and research applications to detect and visualize specific nucleic acid...
Published: 12/4/2024
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Inventor(s): Sanjay Tyagi, Salvatore Marras
Keywords(s): Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
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