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Buccal swab-based biomarkers for schizophrenia
mRNA normalized fold expression from transcript of interest
Invention Summary:
Schizophrenia (SCZ) is a debilitating and chronic brain disorder characterized by symptoms, such as hallucinations, delusions, and disorganized thoughts. Current diagnostic criteria rely solely on behavioral observations and do not account for molecular and clinical...
Published: 4/30/2025
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Inventor(s): Bonnie Firestein-Miller, Irving Vega, Steven Silverstein
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Cell-Based Biosensor for Monitoring Neuronal Stem Cell Differentiation
Movement of fluorescent cargo (EGFP, green) from the cytoplasm to the nucleus (Hoechst, blue) as early as 10 minutes after stimulation with hippocalcin
Invention Summary:
Monitoring neuronal differentiation in stem cells is vital to advance regenerative stem cell therapies and our understanding of various neurodegenerative diseases. Traditional...
Published: 5/7/2025
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Inventor(s): Ki-Bum Lee, Youngeun Kwon, Euiyeon Lee
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
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Novel FISH probes for the prognosis of malignant transformation in Barrett’s epithelium
Left: Translocations as visualized by FISH assay during metaphase. Right: Fusion as visualized in human esophageal adenocarcinoma tissue section
Invention Summary:
Barrett’s epithelium (BE) is a premalignant tissue that can progress into esophageal adenocarcinoma (EA) following the metaplasia→low grade dysplasia→ high grade dysplasia→cancer...
Published: 4/10/2025
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Inventor(s): Kiron Das, Manisha Bajpai, Hana Aviv
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Modified Simmons Catheter
Neurointerventions with improved success
Invention Summary:
The global neurovascular catheter market size was valued at USD 2.88 billion in 2020 and is expected to expand at a compound annual growth rate of 6.7% from 2021 to 2028. Neurointerventionalists, interventional radiologists, cardiologists, and vascular surgeons often can have...
Published: 1/8/2025
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Inventor(s): Amit Singla
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices
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Accelerated Image Reconstruction (MRI)
Comparison of the adaptive unrolled method's effectiveness against two other contemporary deep unrolling techniques (M1 and M2). M1 produces a blurry reconstruction, M2 results in a clear but structurally inaccurate output. In contrast, the adaptive unrolling method achieves reconstruction that closely matches the Ground Truth in both sharpness...
Published: 12/17/2024
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Inventor(s): Bingyu Xin, Dimitris Metaxas
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Imaging, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Artificial Intelligence & Machine Learning
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PRISM: Precise Identification of Species of the Microbiome
Invention Summary:
The human microbiome plays a critical role in health and disease, influencing conditions such as cardiovascular disease, cancer, and autoimmune disorders. However, analysis of microbial genetics data has struggled to overcome the effects of false positive and false negative data. Computational methods are further constrained...
Published: 12/17/2024
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Inventor(s): Bassel Ghaddar, Subhajyoti De
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
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MYC Program as a biomarker of response to treatment with Enzalutamide
Invention Summary:
Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to...
Published: 12/12/2024
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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IDENTIFYING TREATMENT RESPONSE SIGNATURES
Invention Summary:
Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible.
Researchers at Rutgers University have...
Published: 2/20/2025
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Inventor(s): Antonina Mitrofanova, Sukanya Panja
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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Activity-Based Aptamers as Next-Generation Bioimaging Tools and Diagnostics
Invention Summary:
As more and diverse biomarkers are identified for critical pathophysiological processes, there is a growing need to develop easily applied, reliable, and adaptable diagnostic tools.
Rutgers researchers have developed a smart molecular toolbox that fulfill these criteria. This toolbox, termed the activity-based aptamer...
Published: 9/16/2024
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Inventor(s): Enver Izgu, Tushar Aggarwal
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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SuperSelective PCR Primers
Structure of a SuperSelective primer for the detection and quantitation of rare mutant sequences in the presence of 1,000,000 wild-type sequences; and a demonstration that the number of amplification cycles required to generate a signal above background is inversely linearly proportional to the logarithm of the number of mutant molecules in the original...
Published: 4/17/2025
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Inventor(s): Salvatore Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred Kramer
Keywords(s): Anti-cancer, Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
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