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Methods of diagnosing B cell malignancies and detecting B cell malignancy relapse
Workflow schematic of the diagnostic platform for detecting B cell malignancies.
Invention Summary:
B cell malignancies comprise more than 50% of blood cancers and approximately 90% of all lymphomas. Existing technologies for the detection of B cell malignancies include modern imaging technologies, flow cytometry of B cell subpopulations, cytogenetic...
Published: 9/29/2023
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Inventor(s): Ping Xie, Jaeyong Jung, Roger Strair, Samantha Gokhale, Lauri Goodell, Amer Assal
Keywords(s): Cancer biomarkers
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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SAHMI: Microbiome-based screening method for cancer and other diseases
Screening methodology and principle data identifying differences in
microbiome diversity from disease state in pancreatic cancer
Invention Summary:
The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 8/8/2022
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Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Biomarkers for Identifying Patients at High Risk of Progressing
from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary:
Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 9/16/2022
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Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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An Algorithm for Identification of Treatment-response Biomarkers to Chemotherapies
Invention Summary:
In the last decade, several computational methods have been successfully applied to understand cancer initiation and progression through integration of genomic and epigenomic data. However, despite recent advances in discovering a wide array of novel chemotherapy agents, identification of patients with poor and favorable response...
Published: 6/7/2022
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Inventor(s): Antonina Mitrofanova, Nusrat Epsi
Keywords(s): Bioinformatics, Biomarkers, Cancer biomarkers, Data Science, Digital Health
Category(s): Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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DNA Logic-gated Proximity Assembly Circuit for Biochemical Sensing
Schematic summary of the dNANOSIS assay
Invention Summary:
Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid, and low-cost medical diagnosis that can be used by non-specialists at home, in the field or in an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and...
Published: 5/19/2023
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Inventor(s): Jinglin Fu, Sung Won Oh, Adriana Pereira
Keywords(s): Bioengineering scaffolds, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > COVID-19, Technology Classifications > Research Tools, Technology Classifications > Infectious Disease
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Small Molecule Extracellular Inhibitors of TAM Receptors for Cancer Therapy
Invention Summary:
The TAM receptors (Tyro3, Axl, and Mertk) are a family of three homologous receptor tyrosine kinases (RTKs) that play important roles in tissue homeostasis, immune response, and the resolution of inflammation. Besides the intracellular catalytic kinase domain common to all kinases, the TAMs uniquely contain an extracellular domain...
Published: 3/21/2024
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Inventor(s): William Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Stanley Kimani, Thomas Comollo, Kamalendra Singh
Keywords(s): Anti-cancer, Brain Cancer, Breast Cancer, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Automated Detection and Classification of Tumors from Digitized Histological Tissue Specimens
Flowchart illustration of the working of the algorithm
Invention Summary:
Computer-aided diagnosis (CAD) systems can automatically sort digitized medical images which can otherwise be a time-consuming process.
Researchers at Rutgers have developed a CAD method to automatically distinguish between tumor and benign regions in digitized prostate...
Published: 7/21/2022
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Inventor(s): Anant Madabhushi, Michael Feldman, John Tomaszewski
Keywords(s): Cancer biomarkers, Imaging
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Medical Imaging, Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Cancer
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Panel & Software to Predict Therapeutic Resistance in Cancer Treatment
Invention Summary:
According to the American Cancer Society, prostate cancer is the second most common malignancy in men and the second-highest cancer-related cause of death in American men. Androgen deprivation therapy (ADT), which reduces or prevents male hormones (androgens) from interacting with cancer cells, has been shown to be beneficial in...
Published: 10/15/2022
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Inventor(s): Antonina Mitrofanova, Sukanya Panja
Keywords(s): Bioinformatics, Biomarkers, Cancer biomarkers, Digital Health, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Novel anti HER-WL antibodies against cancer-associated antigens
Invention Summary:
Human endogenous retroviruses (HERVs) constitute 8% human genome and are inherited remnants of retroviral integrations in the human genome. Despite being evolutionarily dysfunctional, some cells can code proteins due to epigenetic dysregulation during malignant transformation in cancer or during HIV infection, autoimmune and multi-factorial...
Published: 9/21/2023
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Inventor(s): Vincent Tsiagbe, Yu Li
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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