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Bioinformatic Methods for Determining Resistance to Cancer Treatments
Invention Summary:
Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible.
Researchers at Rutgers University have...
Published: 11/12/2024
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Inventor(s): Antonina Mitrofanova, Sukanya Panja, Sarki Abdulkadir, Vishal Kothari, Edward Schaeffer
Keywords(s): Bioinformatics, Biomarkers, Digital Health, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19
Invention Summary:
Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for...
Published: 11/26/2024
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Inventor(s): Jeisac Guzmán Rivera, Maria Gennaro, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome
Fig 1. The potential added value of testing for novel biomarkers including FCGBP, MRC1, and LBP in children with MIS-C include the quick and accurate diagnosis, treatment, and prognosis.
Invention Summary:
The multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for timely, accurate disease...
Published: 4/21/2024
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Inventor(s): Maria Gennaro, Jeisac Guzmán Rivera, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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SAHMI: Microbiome-based screening method for cancer and other diseases
Screening methodology and principle data identifying differences in
microbiome diversity from disease state in pancreatic cancer
Invention Summary:
The microbiome plays an essential role in the prognosis and progression of disease and health, as seen in cancers like pancreatic cancer. Pancreatic cancer is rising in majority of cancer...
Published: 8/8/2022
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Inventor(s): Subhajyoti De, Bassel Ghaddar
Keywords(s): Anti-cancer, Bioinformatics, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Biomarkers for Identifying Patients at High Risk of Progressing
from Barrett’s Esophagus to Esophageal Adenocarcinoma
Invention Summary:
Esophageal adenocarcinoma (EAC) has a poor prognosis with a 5-year overall survival of 15-20%. In the past 3 decades, the incidence of EAC increased 600-800%. Barrett’s esophagus (BE), the precancerous lesion for EAC, has approximately 0.11 to 1.6% annual rate of progression to EAC. Currently, the guidelines for BE surveillance...
Published: 12/10/2024
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Inventor(s): Zhongren ("David") Zhou
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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An Algorithm for Identification of Treatment-response Biomarkers to Chemotherapies
Invention Summary:
In the last decade, several computational methods have been successfully applied to understand cancer initiation and progression through integration of genomic and epigenomic data. However, despite recent advances in discovering a wide array of novel chemotherapy agents, identification of patients with poor and favorable response...
Published: 6/7/2022
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Inventor(s): Antonina Mitrofanova, Nusrat Epsi
Keywords(s): Bioinformatics, Biomarkers, Cancer biomarkers, Data Science, Digital Health
Category(s): Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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DNA Logic-gated Proximity Assembly Circuit for Biochemical Sensing
Schematic summary of the dNANOSIS assay
Invention Summary:
Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid, and low-cost medical diagnosis that can be used by non-specialists at home, in the field or in an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and...
Published: 5/15/2024
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Inventor(s): Jinglin Fu, Sung Won Oh, Adriana Pereira
Keywords(s): Bioengineering scaffolds, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > COVID-19, Technology Classifications > Research Tools, Technology Classifications > Infectious Disease
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Panel & Software to Predict Therapeutic Resistance in Cancer Treatment
Invention Summary:
According to the American Cancer Society, prostate cancer is the second most common malignancy in men and the second-highest cancer-related cause of death in American men. Androgen deprivation therapy (ADT), which reduces or prevents male hormones (androgens) from interacting with cancer cells, has been shown to be beneficial in...
Published: 10/15/2022
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Inventor(s): Antonina Mitrofanova, Sukanya Panja
Keywords(s): Bioinformatics, Biomarkers, Cancer biomarkers, Digital Health, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Rapid Molecular Assays for Fungal Infections
Sensitivity of real-time NASBA assay for fungi. B: pan-Candida probe, C: pan-Aspergillus probe
Invention Summary:
Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. However, the current standard of care for diagnosis is blood culture, a method limited by the time to diagnosis (1-2 days),...
Published: 6/8/2023
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Inventor(s): David Perlin, Steven Park, David Denning
Keywords(s): Biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Novel anti HER-WL antibodies against cancer-associated antigens
Invention Summary:
Human endogenous retroviruses (HERVs) constitute 8% human genome and are inherited remnants of retroviral integrations in the human genome. Despite being evolutionarily dysfunctional, some cells can code proteins due to epigenetic dysregulation during malignant transformation in cancer or during HIV infection, autoimmune and multi-factorial...
Published: 9/21/2023
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Inventor(s): Vincent Tsiagbe, Yu Li
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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