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Method for Enhancing Immunoregulatory Effect of Stem Cells
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IL-17A promotes MSC-Mediated immunosupressive effect. Changes in cell proliferation as shown in microscopy
Invention Summary:
Autoimmune diseases occur when the immune system attacks the body’s tissue components. Mesenchymal stem/stromal cells (MSCs) have been used as treatment to many autoimmune disorders such as type 1 diabetes,...
Published: 2/20/2026
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Inventor(s): Yufang Shi, Guangwen Ren, Liying Zhang
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
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MaxVac- Powered Toothbrush with Evacuation Technology
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Vacuum-Tooth Brush Attributes:
On-off switch, Easy-Empty (or disposable) fluid & debris collector cup, Ergonomic design, Battery-operated and Affordable.
Invention Summary:
A novel powered toothbrush that couples a vacuum suction and waste container to an existing toothbrush that automatically removes...
Published: 2/20/2026
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Inventor(s): Maxine Strickland, Vivek Kumar
Keywords(s): Cleaning/Disinfecting Products, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Dental, Technology Classifications > Consumer & Household Goods
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Chemogenetic Treatment for Neurodegenerative and Neuropsychiatric Disorders
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DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like...
Published: 2/20/2026
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Inventor(s): Gary Aston-Jones
Keywords(s):
Category(s): Technology Classifications > CNS Disorder, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
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In situ gel vehicle for ophthalmic drug delivery
Polymer compositions were screened with amplitude oscillation and show synergistic effects with simulated tear fluid
Invention Summary:
Effective ophthalmic drug delivery remains a significant challenge due to the eye’s natural defense mechanisms, including blinking, tear turnover, and nasolacrimal drainage, which rapidly clear topically...
Published: 2/20/2026
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Inventor(s): Patrick Sinko, Benjamin Yee, Dayuan Gao
Keywords(s):
Category(s): Technology Classifications > Therapeutics
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Fluorescence Polarization Probe for identifying inhibitors of Enterovirus D68 2C
Design of the 2C fluorescence polarization probe Jun14157 and assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where...
Published: 2/20/2026
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Inventor(s): Jun Wang, Kan Li
Keywords(s):
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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“Y”-shaped symmetric Enterovirus D68 2C inhibitors are antiviral drug candidates
Graphical abstract describing design of “Y”-shaped symmetric 2C inhibitors. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis...
Published: 2/20/2026
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Inventor(s): Jun Wang, Hiwot Demssie
Keywords(s):
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates
Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link).
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts...
Published: 2/20/2026
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav
Keywords(s):
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 2/20/2026
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 2/20/2026
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Ahmadullah Ansari, Francesc Ruiz Figueras, Edward Arnold
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 2/20/2026
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Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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