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PEG Nanocarriers, Nanogels
and Synthesis Methods
Invention Summary:
A novel platform of PEG-only nanocarriers and nanogels has been developed by Rutgers scientists. The nanocarriers can be used from 100Da-100- kDa and are capable of forming stable nanogels and nanogel aggregates in a variety of sizes from 20-30nm up to >1000nm. The carriers and gels have improved solubility over existing technologies...
Published: 12/4/2024
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Inventor(s): Patrick Sinko, Manjeet Deshmukh, Hilliard Kutscher, Stanley Stein, Simi Gunaseelan, Anupa Menjoge
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Doxycycline Loaded Poly(Ethylene Glycol) Hydrogels for Healing Vesicant-Induced Ocular Wounds
Invention Summary:
Rutgers scientists have invented a method of loading poly (ethylene glycol) hydrogels with doxycycline to treat vesicant-induced (i.e. sulfur mustard gas) ocular wounds. The effectiveness of doxycycline, an FDA approved drug in humans, was previously limited in ocular treatment due to tear washing on the eye’s surface. The...
Published: 12/4/2024
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Inventor(s): Patrick Sinko
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Oral Delivery of Therapeutics and Diagnostics using Peptide Ligands
Invention Summary:
Intestinal uptake and absorption of orally administered drugs has been a challenge in the field of drug development and therapeutics research. Rutgers scientists have recently invented a novel mechanism to achieve increased absorption of molecules and to enhance their bioavailability via oral delivery. This invention facilitates...
Published: 12/4/2024
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Inventor(s): Patrick Sinko
Keywords(s): Drug Delivery, Nanoparticles, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Biodegradable PEG Hydrogels and Methods of Use
Invention Summary:
Rutgers scientists have engineered PEG hydrogels that can biodegrade - they provide novel drug delivery capabilities relative to standard PEG technologies. The technology utilizes soluble, biodegradable PEG molecules which are cross-linked in the presence of drug agents. The resulting hydrogels serve as standard depots for sustained...
Published: 12/11/2023
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Inventor(s): Patrick Sinko, Manjeet Deshmukh, Stanley Stein, Simi Gunaseelan, Yashveer Singh
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials
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Nanoparticle Delivery System for the Treatment of Non-Small Cell Lung Cancer and Targeted Cancer Therapy
Invention Summary:
Rutgers scientists have invented a novel treatment strategy that relates to an intravenously (“IV”) administered lung targeted nanoparticle (NP)/ gel microparticle (GMP) delivery system for the treatment of non-small cell lung cancer (NSCLC). The delivery system delivers the chemotherapeutic agent camptothecin (CPT) along...
Published: 12/4/2024
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Inventor(s): Patrick Sinko
Keywords(s): Anti-cancer, Drug Delivery, Nanoparticles
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Novel Monodisperse PEGtide Dendrons as Nanocarrier for Drug Delivery
Representative Structure of PEGtide
Invention Summary:
Dentrimers and dendrons have generated tremendous interest as nanocarriers for various drug delivery applications. Rutgers scientists have developed a series of novel monodisperse PEGtide dendrons with versatility to accommodate various drug delivery demands.
PEGtide dendrons containing...
Published: 12/4/2024
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Inventor(s): Patrick Sinko, Jieming Gao
Keywords(s): Antibacterial, Anti-cancer, Antiviral, Biomaterials
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Resolvable Spray-On Hydrogel as Wound Dressing and Drug Delivery Agent
Invention Summary:
Hydrogel-based wound dressing is an accepted clinical practice for the promotion of wound healing and/or drug delivery. However, current hydrogel-based technologies have disadvantages including difficulty in removal, prone to gelling during packaging or storage, and requiring temperature manipulation before administration.
Rutgers...
Published: 10/16/2024
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Inventor(s): Patrick Sinko, Stanley Stein
Keywords(s): Biomaterials, Cleaning/Disinfecting Products, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials
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