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Immunotherapy for Inflammatory Bowel Disease (IBD)
H&E staining of colons from Zbtb20 WT and Zbtb20 cKO mice treated with DSS. Survival curves for WT and cKO mice following treatment with DSS in drinking water. Adoptive transfer of Zbtb20 expressing Tregs rescues mice from death and protects. Mice are also protected from excessive weight loss (not shown).
Invention Summary:...
Published: 10/21/2024
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Inventor(s): Derek Sant'Angelo, Lisa Denzin
Keywords(s): Autoimmune
Category(s): Technology Classifications > Healthcare & Life Sciences
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Small Molecule Inhibitors of MIF for Inflammatory Diseases
Small molecules targeting to the inflammatory cytokine MIF could be a treatment for various diseases
Invention Summary:
A wide range of diseases can be addressed by targeting inflammatory cytokines. Although there are monoclonal antibody drugs that target, e. g., Tumor Necrosis Factor (TNF), no orally administrable small molecule inhibitor...
Published: 12/4/2024
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Inventor(s): Achyutharao Sidduri
Keywords(s): Autoimmune, Inflammation, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences
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A New Method to Treat Asthma and Allergic Reaction
PBS PeptideIntranasal peptide treatment inhibits ILC2-dependent mucus productionInvention Summary:Although most patients with asthma respond to regular inhaled glucocorticoid (corticosteroid) therapy, 5% to 25% of people with asthma have more severe disease and do not respond...
Published: 12/10/2024
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Inventor(s): Mark Siracusa, Jacques Roberge
Keywords(s): Autoimmune, Peptides, Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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