peptides - Available Technologies | Rutgers University Innovation Ventures

Search Results - peptides

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Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary: The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 12/1/2021   |   Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
Leukemia inhibitory factor- Protective role for radiation/chemo-induced gut syndrome and GVHD
Invention Summary: Currently there is no effective therapy for prevention or treatment of radiation therapy-induced gastrointestinal (GI) tract injury This is also true for Graft-versus-host disease (GVHD) which remains a major complication after allogeneic hematopoietic stem cell transplantation, a widely-used therapy for hematologic malignancies...
Published: 10/14/2021   |   Inventor(s): Wenwei Hu, Zhaohui Feng, Jianming Wang, Huaying Wang
Keywords(s): Anti-cancer, Gastrointestinal disease, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Therapeutics
Cationic Amphiphile for Antimicrobial Applications
The structure of CAms 5a, 5b, 5c, 8a, 8b, and 8c Invention Summary: The development of antibiotic-resistant bacteria is a prevalent concern that has prompted the development of new antimicrobial agents. Naturally-occurring antimicrobial peptides (AMPs) offer advantages over conventional antibiotics due to a reduced development of resistance mechanisms...
Published: 10/1/2021   |   Inventor(s): Kathryn Uhrich, Yingyue Zhang, Allison Faig, Michael (mikhail) Chikindas
Keywords(s): Antibacterial, Biomaterials, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Oral Delivery of Therapeutics and Diagnostics using Peptide Ligands
Invention Summary: Intestinal uptake and absorption of orally administered drugs has been a challenge in the field of drug development and therapeutics research. Rutgers scientists have recently invented a novel mechanism to achieve increased absorption of molecules and to enhance their bioavailability via oral delivery. This invention facilitates...
Published: 11/13/2020   |   Inventor(s): Patrick Sinko
Keywords(s): Drug Delivery, Nanoparticles, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
Modified Kisspeptin Receptor Agonist as Novel Treatment of Non-Fatty Liver Disorder and Non-Alcoholic Steatohepatitis
TAK-448 protected insulin resistant, obese mice against the development of hepatic steatosis: H& E showing fatty liver. Invention Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide that can progress to steatohepatitis (NASH), the leading reason for liver transplants. In the U.S., there are...
Published: 10/22/2020   |   Inventor(s): M. Moshmi Bhattacharya Babwah, Andy Babwah, Sally Radovick, Fredric Wondisford
Keywords(s): Diabetes & Metabolic Disorders, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
A New Method to Treat Asthma and Allergic Reaction
PBS PeptideIntranasal peptide treatment inhibits ILC2-dependent mucus productionInvention Summary:Although most patients with asthma respond to regular inhaled glucocorticoid (corticosteroid) therapy, 5% to 25% of people with asthma have more severe disease and do not respond...
Published: 1/3/2020   |   Inventor(s): Mark Siracusa, Jacques Roberge
Keywords(s): Autoimmune, Peptides, Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Drug Candidate for the Treatment of Dilated Cardiomyopathy
Invention Summary: Dilated cardiomyopathy (DCM) is the most common cause of heart failure. About 5.7 million adults in the United States have heart failure, and approximately half million new cases are diagnosed annually. Patients with DCM can lead to arrhythmias, and about half of people who develop heart failure die within 5 years of diagnosis....
Published: 5/17/2018   |   Inventor(s): Diego Fraidenraich, Qingshi Zhao
Keywords(s): Cardiovascular, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Methods to Produce Hepatitis C Virus E2 Protein
Invention Summary: Rutgers scientists have developed methods to produce and purify the ectodomain of HCV E2, a critical structural protein of the virus that has potential to serve as a vaccine candidate to prevent HCV infection. Efforts to study HCV, and to develop vaccines, have been impaired in part by the inability to produce sufficient quantities...
Published: 6/18/2013   |   Inventor(s): Joseph Marcotrigiano, Jillian Whidby
Keywords(s): Drug Discovery/Screening, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics