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Novel GalNAc-siRNA Conjugates as a Treatment for High Blood Triglycerides and Fatty Liver Disease
H&E staining of mice liver sections showing protection against high blood triglyceride and MASLD induced by a high-fat diet in knockout mice.
Invention Summary:
Diabetes and obesity are the major contributors to the pathological accumulation of triglyceride (TAG) in the blood and liver, resulting in metabolic syndrome, myocardial infarction,...
Published: 8/9/2024
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Inventor(s): Fredric Wondisford, Sally Radovick
Keywords(s): Inflammation
Category(s): Technology Classifications > Healthcare & Life Sciences
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Biodegradable and Biocompatible Polymers for Controlled NSAID Delivery
A. Drug delivery system hydrolysis – composed of 1 (Ibuprofen), 2 (naproxen) and 3 (tartatic acid) into polymer backbones. B. Hydrolytic degradation of the ibuprofen-based polyester.
Invention Summary:
Ibuprofen and naproxen are commonly used to treat pain and swelling associated with rheumatoid arthritis and osteoarthritis....
Published: 11/1/2024
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Inventor(s): Kathryn Uhrich, Roselin Rosario-Melendez
Keywords(s): Biomaterials, Inflammation, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Small Molecule Inhibitors of MIF for Inflammatory Diseases
Small molecules targeting to the inflammatory cytokine MIF could be a treatment for various diseases
Invention Summary:
A wide range of diseases can be addressed by targeting inflammatory cytokines. Although there are monoclonal antibody drugs that target, e. g., Tumor Necrosis Factor (TNF), no orally administrable small molecule inhibitor...
Published: 12/4/2024
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Inventor(s): Achyutharao Sidduri
Keywords(s): Autoimmune, Inflammation, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences
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Kombo Butter Extract and Derivatives as Novel Anti-Inflammatory Agents
Invention Summary:
Rutgers scientists have developed a novel process to isolate the critical bio-active compounds of Kombo butter, which can be used to effectively treat a variety of inflammatory disorders including arthritis/joint or other inflammation (including bowels, gastrointestinal, skin, and allergic), and the presence of associated free radicals....
Published: 4/26/2024
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Inventor(s): James Simon, Mingfu Wang, Mohamed Rafi, Yaw Asianowa, Daniel Acquaye, Kodzo Gbewonyo
Keywords(s): Inflammation, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Agriculture, Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Healthcare & Life Sciences
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Tunable Quantitative Assays
Invention Summary:
Traditional hybridization-based methods used single stranded probes (P) complementary to single stranded target sequences (T).8 Such approaches frequently lacked the stringency to differentiate between P-T perfect matches (primary “hits”) and energetically similar yet imperfect P-M mismatches (secondary “hits”),...
Published: 5/6/2024
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Inventor(s): Kathryn Uhrich
Keywords(s): Biomaterials, Drug Delivery, Inflammation, Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Plant-derived Nutraceutical Compositions containing Phenethylisothiocyanate and their Uses as Anti-Inflammatory Agents
Rat paw edema anti-inflammatory assays demonstrated that treatment with PEITC essential oil (PEO) was as quick and effective as treatment with aspirin.
Invention Summary:
Rutgers scientists have developed proprietary and unique methods for obtaining high yields of phenethyl isothiocyanate (PEITC), a natural glucosinolate derivative known for its...
Published: 11/27/2024
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Inventor(s): Ilya Raskin, Moul Dey, David Ribnicky
Keywords(s): Inflammation, Personal Care, Cosmeceuticals, Wound healing
Category(s): Technology Classifications > Agriculture, Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Healthcare & Life Sciences
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Method for modulating inflammatory responses
Invention Summary:
Cholesterol is a major component of lipid rafts, which are sphingolipid-enriched planar domains of the cell membrane. Rafts play key roles in a variety of the cell signals processes including calcium entry into cells, which activates white blood cells and causes inflammation. Many inflammatory cell responses are tightly controlled...
Published: 3/21/2024
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Inventor(s): Carl Hauser
Keywords(s): Inflammation
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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