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Novel GalNAc-siRNA Conjugates as a Treatment for High Blood Triglycerides and Fatty Liver Disease
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H&E staining of mice liver sections showing protection against high blood triglyceride and MASLD induced by a high-fat diet in knockout mice.
Invention Summary:
Diabetes and obesity are the major contributors to the pathological accumulation of triglyceride (TAG) in the blood and liver, resulting in metabolic syndrome, myocardial infarction,...
Published: 8/9/2024
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Inventor(s): Fredric Wondisford, Sally Radovick
Keywords(s): Inflammation
Category(s): Technology Classifications > Healthcare & Life Sciences
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Small Molecule Inhibitors of MIF for Inflammatory Diseases
Small molecules targeting to the inflammatory cytokine MIF could be a treatment for various diseases
Invention Summary:
A wide range of diseases can be addressed by targeting inflammatory cytokines. Although there are monoclonal antibody drugs that target, e. g., Tumor Necrosis Factor (TNF), no orally administrable small molecule inhibitor...
Published: 8/12/2025
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Inventor(s): Achyutharao Sidduri
Keywords(s): Autoimmune, Inflammation, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences
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Plant-derived Nutraceutical Compositions containing Phenethylisothiocyanate and their Uses as Anti-Inflammatory Agents
Rat paw edema anti-inflammatory assays demonstrated that treatment with PEITC essential oil (PEO) was as quick and effective as treatment with aspirin.
Invention Summary:
Rutgers scientists have developed proprietary and unique methods for obtaining high yields of phenethyl isothiocyanate (PEITC), a natural glucosinolate derivative known for its...
Published: 8/12/2025
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Inventor(s): Ilya Raskin, Moul Dey, David Ribnicky
Keywords(s): Inflammation, Personal Care, Cosmeceuticals, Wound healing
Category(s): Technology Classifications > Agriculture, Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Healthcare & Life Sciences
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