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Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer
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Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models.
Invention Summary:
Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...
Published: 8/20/2025
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Inventor(s): Sungyun Kim, Ki-Bum Lee, Hyun-Jong Cho
Keywords(s): Anti-cancer, Breast Cancer, Drug Delivery, Nanotechnology, Wound healing
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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New Vector Platform for Concurrent Tumor Imaging, Therapy, and Evaluation of Response to Therapy
Diagnosis of HER2+ cancer metastasis lesions in mouse using a genetically engineered targeted vector in conjunction with MRI. The MRI followed by voxel-by-voxel analysis of scans showed that the vector makes it possible to differentiate HER2+ from HER2- cancer lesions in mouse lungs
Invention Summary:
The human epidermal growth factor receptor-2...
Published: 8/12/2025
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Inventor(s): Arash Hatefi
Keywords(s): Breast Cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Predicting Therapeutic Resistance to Tamoxifen in Cancer Treatment
Invention Summary:
Currently, patients with ER+ breast cancer are administered tamoxifen without considering their potential response to this therapy. Thousands of women take the tamoxifen only to discover that their tumors do not respond or that they develop resistance over time. The ability to screen patients ahead of the therapy administration...
Published: 8/12/2025
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Inventor(s): Antonina Mitrofanova, Sarra Rahem
Keywords(s): Bioinformatics, Breast Cancer, Data Science, Digital Health
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Inhibitors of Gas6-Axl Signaling Pathway as First of Kind Cancer Therapeutics
Gas6 activates TAM receptor (Axl)inducing signaling cascade to promote tumor cell proliferation, migration and survival.
Invention Summary:
TAM receptors (Tyro-3, Axl, and Mer) belong to a family of receptor tyrosine kinases (RTKs) that play essential roles in homeostasis and inflammation. Axl is overexpressed in many human cancers and is clinically...
Published: 12/8/2025
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Inventor(s): William Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Stanley Kimani, Thomas Comollo, Kamalendra Singh
Keywords(s): Anti-cancer, Brain Cancer, Breast Cancer, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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