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Sigma-1 Receptor Antagonists – Non-Addictive Pain Management

Invention Summary: The sigma 1 receptor (S1R), a molecular chaperone protein located in the endoplasmic reticulum and plasma membranes, plays important roles in various pathological disorders including pain. The potential commercial applications of novel S1R antagonists are twofold: 1) as stand-alone therapy for the treatment of chronic neuropathic...

Published: 12/12/2025 | Inventor(s): William Welsh, Youyi Peng

Keywords(s): Antiviral, Neurological disorder & neuropathic pain, Small molecules

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Inhibitors of Gas6-Axl Signaling Pathway as First of Kind Cancer Therapeutics

Gas6 activates TAM receptor (Axl)inducing signaling cascade to promote tumor cell proliferation, migration and survival. Invention Summary: TAM receptors (Tyro-3, Axl, and Mer) belong to a family of receptor tyrosine kinases (RTKs) that play essential roles in homeostasis and inflammation. Axl is overexpressed in many human cancers and is clinically...

Published: 12/8/2025 | Inventor(s): William Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Stanley Kimani, Thomas Comollo, Kamalendra Singh

Keywords(s): Anti-cancer, Brain Cancer, Breast Cancer, Cancer biomarkers

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics