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miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning.
Invention Summary:
Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024
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Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Enzyme Catalyzed Toehold Mediated Strand Displacement (TMSD)
Invention Summary:
Toehold mediated strand displacement (TMSD) is widely used in nanotechnology applications such as DNA nano-circuits and devices. The toeholds which are small single‐stranded DNA overhangs, are often utilized in kinetically controlled complex biochemical circuits. Existing toehold mediated strand displacement (TMSD)...
Published: 1/24/2023
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Inventor(s): Smita Patel, Laura Johnson, Gayatri Patel, Anupam Singh
Keywords(s): Biosensor, Catalysts, Nanotechnology
Category(s): Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences
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Nanosphere Size Control by Varying the Ratio of Copolymer Blends
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Schematic showing the process of creating drug-loaded nanospheres
Invention Summary:
Recent advances in nanotechnology have demonstrated the advantages of encapsulating poorly bioavailable drugs in nanometer-sized spheres (nanospheres) and deliver them in a targeted manner....
Published: 2/5/2024
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Inventor(s): Joachim Kohn, Mariana Reis Nogueira de Lima
Keywords(s): Biomaterials, Drug Delivery, Nanotechnology, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
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Paper-Based Nano-Biosensor for Cytokine Detection
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Invention Summary:
Cytokines are a class of regulatory proteins that are important physiological and pathological markers commonly used for the prognosis and diagnosis of diseases such as cancer, Alzheimer’s and rheumatoid arthritis, as well as for monitoring responses to injuries.
Researchers at Rutgers University have...
Published: 6/13/2024
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Inventor(s): Aaron Mazzeo, Francois Berthiaume, Ali Ashraf, Ramendra Pal
Keywords(s): Biosensor, Graphene technology, Nanotechnology, Polymers & Composites, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
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Film Forming Foam (FFF) for Burn Wounds/Burnflex
Invention Summary:
Many available dressings on the market use latex, PVC, or polyurethane as barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may be coated in silver sulfadiazine,...
Published: 9/12/2024
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Inventor(s): Maricely Ramírez-Hernández, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
Keywords(s): Antibacterial, Drug Delivery, Nanoparticles, Nanotechnology, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Consumer & Household Goods
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A New Method to Enhance Lung Cancer Treatment
Invention Summary:
Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer. Small molecule Tyrosine Kinase (TK) Inhibitors acting on the Epidermal Growth Factor Receptors (EGFRs) are standard therapies for patients with NSCLC harboring EGFR-TK inhibitor-sensitizing mutations. However, fewer than 10 % of patients with NSCLC benefit...
Published: 4/21/2024
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Inventor(s): Tamara Minko, Olga Garbuzenko
Keywords(s): Drug Delivery, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Nanotechnology
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Internal Vibration Isolation for A Cryogen-free Cryostat to Operate Scanning Tunneling Microscopes
Invention Summary:
Cryogen-free cryostats have attracted attention due to their significant reduction in cost and labor to cool systems to cryogenic temperatures. With cryogen-free cryostats helium does not need to be refilled, which allows experiments to run indefinitely without interruption. This also means that the costly drawing from the worlds...
Published: 10/21/2024
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Inventor(s): Angela Coe, Guohong Li, Eva Andrei
Keywords(s): Imaging, Machines & Instruments, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering
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Compact, Transferable and Modular Scanning Probe Microscope Head
Scanning probe microscope head
Invention Summary:
Scanning probe microscopy (SPM) offers access to material characteristics at the nanometer scale. However, integrating SPMs into research environments poses challenges: incompatibility with cryogenic temperature and high magnetic fields, noisy laboratory environment, and integration issues with...
Published: 10/21/2024
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Inventor(s): Angela Coe, Guohong Li, Eva Andrei
Keywords(s): Imaging, Machines & Instruments, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering
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Polyaniline-Derived N- and O-Doped Mesoporous Carbon:
Electrocatalysts for Oxygen Reduction Reaction (ORR)
Invention Summary:
In the face of global problems associated with the lack of sustainable and renewable energy sources and environmental pollutions caused by fossil fuels, fuel cells have long been expected to contribute to the solutions to these daunting problems by helping to produce electricity from fuels such as hydrogen. Unfortunately, the electrodes...
Published: 9/12/2024
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Inventor(s): Tewodros Asefa, Rafael da Silva
Keywords(s): Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Nanotechnology
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Nanotechnology-based Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases
Two-in-one: Combined nanocarrier based targeted chemo and gene therapy
1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human...
Published: 3/1/2024
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Inventor(s): Tamara Minko, Olga Garbuzenko, Oleh Taratula, Lorna Rodriguez-Rust, Vatsal Shah
Keywords(s): Anti-cancer, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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