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Multi-Faceted Anti-inflammatory Neuroprotective Nanoparticles for Treating Alzheimer’s Disease
Invention Summary:
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and a high mortality rate in the elderly. Current therapeutic strategies fall short in halting the underlying cognitive decline and nerve cell damage. The primary features of AD are the accumulation of extracellular amyloid plaques, uncontrolled...
Published: 4/25/2024
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Inventor(s): Hoda Gebril, Prabhas Moghe, Kathryn Uhrich
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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In situ formation of 2D nanoparticles within elastomers for electromechanical sensing and flexible pressure pad
Adding graphite and elastomer to batch mixer for in situ exfoliation
Invention Summary:
It has been known that a material’s electrical, mechanical, and chemical properties can be enhanced with the addition of graphene nanoparticles. Typically, the nanoparticles are created separately from the bulk material and are injected into...
Published: 9/14/2023
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Inventor(s): Jennifer Lynch-Branzoi, Ali Ashraf, MD Rahman, Nazmul Islam
Keywords(s):
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Polymers/Composites/Materials
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Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
Schematic representation of MitoScript and its components
Invention Summary:
Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 4/25/2024
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s):
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Repurposing Anthelmintics: Effects of Rafoxanide and Copper-Functionalized SBA-15 Carriers Against Methicillin-Resistant Staphylococcus aureus
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Invention Summary:
Due to the rise in bacterial resistance to conventional antibiotics, materials that can administer antimicrobial drugs in a regulated manner more effectively are critically needed. While new antibiotic classes are created and widely used, existing,...
Published: 4/25/2024
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Inventor(s): Maricely Ramírez-Hernández, Javiera Norambuena-Morales, Tewodros Asefa, Jeffrey Boyd
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Animal Health & Care, Technology Classifications > Biomaterials, Technology Classifications > Nanotechnology
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Spatial Dopant Separation using Core-Shell Architecture For Upconversion Luminescent Enhancement in the Erbium-Doped System
Invention Summary:
Upconversion nanoparticles (UCNPs) have gained increasing attention for various biomedical applications due to their high photostability, low autofluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emission intensities due to undesirable energy back-transfer. Further, the use of high-power density...
Published: 10/12/2022
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Inventor(s): Ki-Bum Lee, Hudifah Rabie, Nicholas Pasquale
Keywords(s): Imaging, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Medical Imaging
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High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues.
Invention Summary:
Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming. In nature,...
Published: 10/12/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Film Forming Foam (FFF) for Burn Wounds/Burnflex
Invention Summary:
Many available dressings on the market use latex, PVC, or polyurethane as barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may be coated in silver sulfadiazine,...
Published: 4/21/2024
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Inventor(s): Maricely Ramírez-Hernández, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
Keywords(s): Antibacterial, Drug Delivery, Nanoparticles, Nanotechnology, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Consumer & Household Goods
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A New Method to Enhance Lung Cancer Treatment
Invention Summary:
Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer. Small molecule Tyrosine Kinase (TK) Inhibitors acting on the Epidermal Growth Factor Receptors (EGFRs) are standard therapies for patients with NSCLC harboring EGFR-TK inhibitor-sensitizing mutations. However, fewer than 10 % of patients with NSCLC benefit...
Published: 4/21/2024
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Inventor(s): Tamara Minko, Olga Garbuzenko
Keywords(s): Drug Delivery, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Nanotechnology
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Polyaniline-Derived N- and O-Doped Mesoporous Carbon:
Electrocatalysts for Oxygen Reduction Reaction (ORR)
Invention Summary:
In the face of global problems associated with the lack of sustainable and renewable energy sources and environmental pollutions caused by fossil fuels, fuel cells have long been expected to contribute to the solutions to these daunting problems by helping to produce electricity from fuels such as hydrogen. Unfortunately, the electrodes...
Published: 8/31/2022
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Inventor(s): Tewodros Asefa, Rafael da Silva
Keywords(s): Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Nanotechnology
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Multifunctional Rare Earth-Based Biophotonic Composites
Image showing use of bio-encapsulated Rare Earth (RE) doped nanoparticles targeting melanoma cells.
Invention Summary:
Researchers at Rutgers University have developed new rare earth (RE)-based light-emitting, multifunctional composites for use in various biomedical applications, such as non-invasive imaging, image–guided interventions, drug...
Published: 2/19/2024
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Inventor(s): Prabhas Moghe, Richard Riman, Charles Roth, Mei-Chee Tan, Dominik Naczynski
Keywords(s): Imaging, Nanoparticles
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Imaging, Technology Classifications > Nanotechnology
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