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Novel GalNAc-siRNA Conjugates as a Treatment for High Blood Triglycerides and Fatty Liver Disease
H&E staining of mice liver sections showing protection against high blood triglyceride and MASLD induced by a high-fat diet in knockout mice.
Invention Summary:
Diabetes and obesity are the major contributors to the pathological accumulation of triglyceride (TAG) in the blood and liver, resulting in metabolic syndrome, myocardial infarction,...
Published: 8/9/2024
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Inventor(s): Fredric Wondisford, Sally Radovick
Keywords(s): Inflammation
Category(s): Technology Classifications > Healthcare & Life Sciences
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Expanding Human Primary Liver Tissues into Functional Organoids
Invention Summary:
Chronic liver diseases account for approximately two million deaths per year- one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Unfortunately, there are few treatment options for these conditions, and they commonly require organ transplants. The primary...
Published: 12/16/2024
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Inventor(s): Hatim Sabaawy, Fredric Wondisford
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Modified Kisspeptin Receptor Agonist as Novel Treatment of Non-Fatty Liver Disorder and Non-Alcoholic Steatohepatitis
TAK-448 protected insulin resistant, obese mice against the development of hepatic steatosis:
H& E showing fatty liver.
Invention Summary:
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide that can progress to steatohepatitis (NASH), the leading reason for liver transplants. In the U.S., there are...
Published: 10/14/2024
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Inventor(s): M. Moshmi Bhattacharya Babwah, Andy Babwah, Sally Radovick, Fredric Wondisford
Keywords(s): Diabetes & Metabolic Disorders, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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