|
NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level
NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription.
Invention Summary:
As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating...
Published: 11/25/2024
|
Inventor(s): Ki-Bum Lee, Sy-Tsong Chueng, Hyeon-Yeol Cho, Young Sup Yoon
Keywords(s): Nanoparticles
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
|
|
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning.
Invention Summary:
Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024
|
Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
|
|
Efficient Optical Method for Measuring the Length Distribution of Nanotubes, Nanowires and other 1D Nanoparticles
The effect of the magnitude of electric field on nanoparticle alignment
Invention Summary:
One-dimensional nanomaterials, such as carbon nanotubes (CNTs) or metal nanowires have unique properties such as high electrical and high thermal conductivities which are influenced by the length of the particles. In order to tune the process to obtain...
Published: 6/19/2024
|
Inventor(s): Jerry Shan, Richard Castellano
Keywords(s): Imaging, Machines & Instruments, Nanoparticles, Spectroscopy
Category(s): Technology Classifications > Physical Sciences & Engineering
|
|
Amphiphilic Polymer Stabilized Nanoparticles with Enhanced Biological Stability and Activity
Experimental oxLDL macrophage cellular uptake results after 24-hr incubation with AM micelle or NP configurations under serum free conditions (white bars), 5% FBS (gray bars) and 20% FBS (black bars).
Invention Summary:
According to Centers for Disease Control and Prevention nearly 25% of deaths in the US is due to cardiovascular...
Published: 12/4/2024
|
Inventor(s): Kathryn Uhrich, Prabhas Moghe, Adam York, Robert Prud'homme
Keywords(s): Biomaterials, Cardiovascular, Drug Delivery, Nanoparticles, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
|
|
Film Forming Foam (FFF) for Burn Wounds/Burnflex
Invention Summary:
Many available dressings on the market use latex, PVC, or polyurethane as barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may be coated in silver sulfadiazine,...
Published: 9/12/2024
|
Inventor(s): Maricely Ramírez-Hernández, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
Keywords(s): Antibacterial, Drug Delivery, Nanoparticles, Nanotechnology, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Consumer & Household Goods
|
|
A New Method to Enhance Lung Cancer Treatment
Invention Summary:
Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer. Small molecule Tyrosine Kinase (TK) Inhibitors acting on the Epidermal Growth Factor Receptors (EGFRs) are standard therapies for patients with NSCLC harboring EGFR-TK inhibitor-sensitizing mutations. However, fewer than 10 % of patients with NSCLC benefit...
Published: 4/21/2024
|
Inventor(s): Tamara Minko, Olga Garbuzenko
Keywords(s): Drug Delivery, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Nanotechnology
|
|
Multifunctional Rare Earth-Based Biophotonic Composites
Image showing use of bio-encapsulated Rare Earth (RE) doped nanoparticles targeting melanoma cells.
Invention Summary:
Researchers at Rutgers University have developed new rare earth (RE)-based light-emitting, multifunctional composites for use in various biomedical applications, such as non-invasive imaging, image–guided interventions, drug...
Published: 6/6/2024
|
Inventor(s): Prabhas Moghe, Richard Riman, Charles Roth, Mei-Chee Tan, Dominik Naczynski
Keywords(s): Imaging, Nanoparticles
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Imaging, Technology Classifications > Nanotechnology
|
|
Nanotechnology-based Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases
Two-in-one: Combined nanocarrier based targeted chemo and gene therapy
1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human...
Published: 3/1/2024
|
Inventor(s): Tamara Minko, Olga Garbuzenko, Oleh Taratula, Lorna Rodriguez-Rust, Vatsal Shah
Keywords(s): Anti-cancer, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
|
|
Oral Delivery of Therapeutics and Diagnostics using Peptide Ligands
Invention Summary:
Intestinal uptake and absorption of orally administered drugs has been a challenge in the field of drug development and therapeutics research. Rutgers scientists have recently invented a novel mechanism to achieve increased absorption of molecules and to enhance their bioavailability via oral delivery. This invention facilitates...
Published: 12/4/2024
|
Inventor(s): Patrick Sinko
Keywords(s): Drug Delivery, Nanoparticles, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
|
|
Nanoparticle Delivery System for the Treatment of Non-Small Cell Lung Cancer and Targeted Cancer Therapy
Invention Summary:
Rutgers scientists have invented a novel treatment strategy that relates to an intravenously (“IV”) administered lung targeted nanoparticle (NP)/ gel microparticle (GMP) delivery system for the treatment of non-small cell lung cancer (NSCLC). The delivery system delivers the chemotherapeutic agent camptothecin (CPT) along...
Published: 12/4/2024
|
Inventor(s): Patrick Sinko
Keywords(s): Anti-cancer, Drug Delivery, Nanoparticles
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
|
