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MicroRNA Based Therapeutics for Parkinson’s Disease
Protection of the mouse brain by microRNA-7 against the toxicity of a-synuclein (A) Tyrosine hydroxylase (TH) stained coronal section of mouse brain injected in the right striatum with AAV-miR-7 or non-targeting (NT) vector following by a-synuclein preformed fibrils (PFF) or PBS. (B) Substantia nigra sections. (C) Nigral dopamine neuron count. (D) Striatal...
Published: 12/9/2022
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Inventor(s): M. Maral Mouradian, Eunsung Junn
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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MicroRNA-7 Gene Therapy Promotes Functional Recovery
Following Spinal Cord Injury
Following sever spinal cord compression, the AAV-miR-7 injected mice showed improved locomotor recovery, which is characterized by the Basso Mouse Scale (BMS).
Invention Summary:
Spinal cord injury (SCI) results in partial or complete loss of sensory or motor function. According to the National Spinal Cord Injury Statistical Center,...
Published: 10/21/2024
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Inventor(s): M. Maral Mouradian, Eunsung Junn, Myung-Sik Yoo
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
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Combination of two compounds present in Coffee Synergize to Protect against Parkinson’s & other Neurodegenerative Disorders
Synergistic neuroprotection by two compounds found in coffee (EHT/Caffeine) slow down brain degeneration in models of Parkinson’s Disease and Dementia with Lewy Bodies
Invention Summary:
Parkinson's disease (PD) is the second most common neurodegenerative disorder, and Dementia with Lewy bodies (DLB) is the second most common type of dementia...
Published: 2/20/2024
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Inventor(s): M. Maral Mouradian, Jeffry Stock
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Food, Nutrition and Nutraceuticals
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