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High-Efficiency Electrospray Deposition for Sub-Plume-Scale Surfaces
Schematic of the electrospray setup. (a) Schematic and (b) photograph of an electrospray deposition experiment. White dashed lines are provided as a guide to the eye of the plume. (c) Schematic of the improved spray system and process, highlighting different enhancements (E#). In stage 1, a negative polarity spray (E1) is sprayed directly at a large...
Published: 3/27/2026
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Inventor(s): Jonathan Singer, Sarah Park
Keywords(s): Biomaterials
Category(s): Technology Classifications > COVID-19, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Vaccine
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SARS-CoV-2 Papain-Like Protease (PLpro) Inhibitors
Invention Summary:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a global health risk despite the availability of vaccines and two oral antivirals, molnupiravir and Paxlovid. Limitations including modest efficacy, drug–drug interactions, and the emergence of resistance, particularly to nirmatrelvir, highlight...
Published: 3/27/2026
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > COVID-19
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Diagnostic Assays and Methods for Detecting Pathogens
A novel sample processing method for the co-extraction of DNA/RNA from Mycobacterium tuberculosis (TB) and SARS-COV-2, complementing a novel near-patient CRISPR test for tuberculosis detection (CRISPR SHINE TB).
Invention Summary:
Tuberculosis and COVID-19 are infectious diseases with high mortality rates caused by Mycobacterium tuberculosis...
Published: 2/20/2026
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Inventor(s): Padmapriya Banada, Nisha Modi, Alexandra Bell, Owen Dunkley, Yingda Xie, Cameron Myhrvold
Keywords(s):
Category(s): Technology Classifications > Diagnostics, Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates
Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link).
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts...
Published: 2/20/2026
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav
Keywords(s):
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 2/20/2026
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Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19
Invention Summary:
Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical...
Published: 2/20/2026
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences
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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19
Invention Summary:
Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for...
Published: 2/20/2026
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Inventor(s): Jeisac Guzmán Rivera, Maria Gennaro, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Decentralized, Privacy-preserving Navigation Recommendation System
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The recommendation system provides a proactive and personalized route for a user’s movement indoors or outdoors.
Invention Summary:
Contact tracing has been shown to be an effective disease control measure and a key strategy for preventing further spread of the COVID-19 pandemic. However, smartphone contact tracing tools have...
Published: 2/20/2026
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Inventor(s): Dario Pompili, Saman Aliari Zonouz, Vidyasagar Sadhu
Keywords(s): Wireless
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > COVID-19, Technology Classifications > Software & Algorithms, Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Healthcare & Life Sciences
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Two-Way Knowledge Distillation for Federated Learning
The workflow of the Fed2KD framework. Red arrows indicate the knowledge distillation direction.
Invention Summary:
Current contact tracing reporting platforms for infectious diseases are limited by their reactive nature, centralized approach, use of GPS, and privacy risk due to exchange of user data. Existing federated learning (FL) frameworks...
Published: 2/20/2026
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Inventor(s): Dario Pompili, Chuanneng Sun
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > COVID-19, Technology Classifications > Software & Algorithms
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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome
Fig 1. The potential added value of testing for novel biomarkers including FCGBP, MRC1, and LBP in children with MIS-C include the quick and accurate diagnosis, treatment, and prognosis.
Invention Summary:
The multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for timely, accurate disease...
Published: 2/20/2026
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Inventor(s): Maria Gennaro, Jeisac Guzmán Rivera, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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