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Plant-based system for generation of single-domain antibodies to combat viral infections
Plant-derived antibodies designed to target SARS- CoV-2 bind to SARS-CoV2 spike protein similar to bacteria derived antibodies based on ELISA.
Invention Summary:
The use of neutralizing antibodies is a strategy for treating viral infections, especially for individuals who are immunocompromised or have high-risk medical conditions. Mass production...
Published: 4/21/2024
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Inventor(s): Tamara Minko, Natalia Pogrebnyak, Andrew Shen, Obeid Malekshah
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Vaccine
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A New Method to Enhance Lung Cancer Treatment
Invention Summary:
Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer. Small molecule Tyrosine Kinase (TK) Inhibitors acting on the Epidermal Growth Factor Receptors (EGFRs) are standard therapies for patients with NSCLC harboring EGFR-TK inhibitor-sensitizing mutations. However, fewer than 10 % of patients with NSCLC benefit...
Published: 4/21/2024
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Inventor(s): Tamara Minko, Olga Garbuzenko
Keywords(s): Drug Delivery, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer, Technology Classifications > Nanotechnology
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Nanotechnology-based Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases
Two-in-one: Combined nanocarrier based targeted chemo and gene therapy
1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human...
Published: 3/1/2024
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Inventor(s): Tamara Minko, Olga Garbuzenko, Oleh Taratula, Lorna Rodriguez-Rust, Vatsal Shah
Keywords(s): Anti-cancer, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Nanotechnology Approach for Inhalation Treatment
of Pulmonary (Lung) Fibrosis
Inhalation Treatment
Invention Summary:
Idiopathic Pulmonary Fibrosis (IPF), the spontaneous development of scar tissue within the lungs, is a progressive fibrotic disease that impairs the lung’s ability to get oxygen. To date, its pathogenesis remains elusive and the survival time of patients is between three and five years. Pirfenidone, an...
Published: 3/1/2024
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Inventor(s): Tamara Minko, Vera Ivanova, Olga Garbuzenko
Keywords(s): Nanoparticles, Nanotechnology, Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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