|
Fluorescence Polarization Probe for identifying inhibitors of Enterovirus D68 2C
Design of the 2C fluorescence polarization probe Jun14157 and assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where...
Published: 8/12/2025
|
Inventor(s): Jun Wang, Kan Li
Keywords(s):
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
|
|
“Y”-shaped symmetric Enterovirus D68 2C inhibitors are antiviral drug candidates
Graphical abstract describing design of “Y”-shaped symmetric 2C inhibitors. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis...
Published: 8/12/2025
|
Inventor(s): Jun Wang, Hiwot Demssie
Keywords(s):
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Medical
|
|
New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates
Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link).
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts...
Published: 8/8/2025
|
Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav
Keywords(s):
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
|
|
Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025
|
Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
|
|
Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
|
|
Novel Antibiotic Inhibiting Elongation Factor Complex in Gram-Positive Bacteria
Invention Summary:
Antibiotic resistance remains a global health challenge with millions of related deaths each year. Gram-positive bacterial infections, like those caused by Staphylococcus aureus, are likely to acquire and develop resistance to clinically available antibiotics. Therefore, it is crucial to identify and develop novel antibiotics...
Published: 8/12/2025
|
Inventor(s): Wlodek Mandecki, Emanuel Goldman, Maxim Chudaev, Mark Henderson, Juan Marugan, Wenjuan Ye, Kenneth Wilson, Dane Parker
Keywords(s): Antibacterial, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
|
|
ANTIBACTERIAL AGENTS: DUAL-TARGETED RNA POLYMERASE INHIBITORS (BENZOXAZINO-RIFAAAPS
Invention Summary:
RifaAAPs are novel dual-targeted, low-resistance-emergence, orally-available compounds for treatment of tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections--including drug-resistant, multi-drug-resistant (MDR), and extensively-drug-resistant (XDR) strains.
Researchers indicate that RifaAAPs comprise...
Published: 8/12/2025
|
Inventor(s): Richard Ebright, Yon Ebright, Chih-Tsung Lin
Keywords(s): Antibacterial
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Healthcare & Life Sciences
|
|
Treatments for drug-susceptible and drug-resistant bacterial infections: arylmyxopyronins (APYs)
Invention Summary:
APYs are novel, orally available compounds for treatment of infections caused by Gram-positive bacterial pathogens, fastidious Gram-negative bacterial pathogens, and some non-fastidious Gram-negative bacterial pathogens--including drug-resistant and multi-drug-resistant (MDR) strains.
Our researchers have indicated...
Published: 7/9/2025
|
Inventor(s): Richard Ebright, Yon Ebright
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
|
|
Enterovirus D68 capsid inhibitors as antivirals
Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947.
Invention Summary:
Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...
Published: 1/27/2025
|
Inventor(s): Jun Wang, Yanmei Hu, Kan Li
Keywords(s): Antibacterial, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
|
|
Application of a PS-Targeting Molecule Combined with Memory T cell Antigen for Therapeutic, Diagnostic, and Adjuvant Use
PS binding molecules could restore inactive or memory T cell functions.
Invention Summary:
Phosphatidylserine (PS) exposure on the cell surface is often a signal for phagocytosis and can lead to an immunosuppressive effect. Therefore, its inhibition by PS-binding biomolecules can promote a more immuno-responsive microenvironment. However,...
Published: 1/21/2025
|
Inventor(s): Alok Choudhary
Keywords(s): Antibacterial, Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Infectious Disease, Technology Classifications > Healthcare & Life Sciences
|
