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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19
Invention Summary:
Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for...
Published: 11/26/2024
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Inventor(s): Jeisac Guzmán Rivera, Maria Gennaro, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome
Fig 1. The potential added value of testing for novel biomarkers including FCGBP, MRC1, and LBP in children with MIS-C include the quick and accurate diagnosis, treatment, and prognosis.
Invention Summary:
The multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for timely, accurate disease...
Published: 4/21/2024
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Inventor(s): Maria Gennaro, Jeisac Guzmán Rivera, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2.
Invention Summary:
Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 8/20/2024
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Inventor(s): Jun Wang, Edward Arnold, Francesc Ruiz Figueras, Prakash Jadhav, Bin Tan, Ahmadullah Ansari, Ashima Chopra
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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New Antimalarials Based on the TBN Scaffold
Invention Summary:
Malaria infects over 200 million people and results in nearly half a million deaths as well as up to $12 billion USD in lost economic activity. Although the prevalence of malaria has decreased steadily over the last two decades, progress has stagnated in recent years due to the emergence of drug-resistant malarial strains. These...
Published: 7/16/2024
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Inventor(s): Spencer Knapp, Robert Barrows, Rodney Kiplin Guy, Jared Hammill, Christopher Davis
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Novel Maturation‐defective Attenuated Chlamydia Vaccine
Invention Summary:
Millions of American men and women are infected with Chlamydia each year. Without proper treatment, a substantial proportion of chlamydia-infected women may develop infertility and other health problems. To date, no Chlamydia vaccine is available.
Chlamydia is an obligate intracellular bacterium with a unique...
Published: 5/2/2024
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Inventor(s): Huizhou Fan
Keywords(s): Gene editing
Category(s): Technology Classifications > Vaccine, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Fluorescent Probe for Bacterial Cell Imaging and Screening of New Antibacterial Drugs
Visualization of the impact of FtsZ-targeting drug treatment in both Gram-positive and Gram-negative bacterial strains using BOFP. Bacteria were labeled with BOFP for 5 minutes just prior to visualization. Differential interference contrast (DIC) shows unstained bacteria and fluorescence shows BOFP-labeled bacteria.
Invention Summary:
At least 2.8...
Published: 4/21/2024
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Inventor(s): Daniel Pilch, Edgar Ferrer-Gonzalez, Edmond LaVoie
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Research Tools
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DNA Logic-gated Proximity Assembly Circuit for Biochemical Sensing
Schematic summary of the dNANOSIS assay
Invention Summary:
Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid, and low-cost medical diagnosis that can be used by non-specialists at home, in the field or in an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and...
Published: 5/15/2024
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Inventor(s): Jinglin Fu, Sung Won Oh, Adriana Pereira
Keywords(s): Bioengineering scaffolds, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > COVID-19, Technology Classifications > Research Tools, Technology Classifications > Infectious Disease
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Biosensors for Real-Time Antimicrobial Susceptibility Testing
(A) A schematic of the biosensor. (B) Real time detection of the effect of antibiotics (Ampicillin) on the growth of E. coli. (C) and (D) Real time detection of the effect of antifungal agents Miconazole and Amphotericin B on the growth of yeast.
Invention Summary:
Antimicrobial resistance (AMR) is becoming a major global-health concern. Traditional...
Published: 10/12/2022
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Inventor(s): Yicheng Lu, Pavel Reyes, Steven Zheng, Andrew Zheng, Keyang Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Electronics/Semiconductor, Technology Classifications > Infectious Disease
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