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Small Molecule mGlur5 Agonists for Remyelination in Multiple Sclerosis
Invention Summary:
Multiple sclerosis (MS) is a debilitating autoimmune condition caused by an overactive immune system that destroys the myelin surrounding nerves cells. Symptoms of MS include pain, impaired coordination, vision loss, and overall weakness. Current treatment options work to suppress the immune system to slow progression of...
Published: 6/5/2026
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Inventor(s): Hiroko Nobuta, Jacques Roberge, Cheryl Dreyfus, Yangyang Huang, Pingyue Pan
Keywords(s):
Category(s): Technology Classifications > CNS Disorder, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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RNA-Aptamer-Mediated CRISPR Base Editing Platform for Agriculture License
Description of the base editing (BE) platform and proof of principle in prokaryotic. (A) Components of the platform.
(B) Schematic of the modular complex at the target sequence. Collantes, J C et al. The CRISPR journal (2021).
Invention Summary:
The CRISPR/Cas system has become a foundational technology for precision genome engineering...
Published: 6/5/2026
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Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
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Method for Enhancing Immunoregulatory Effect of Stem Cells
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IL-17A promotes MSC-Mediated immunosupressive effect. Changes in cell proliferation as shown in microscopy
Invention Summary:
Autoimmune diseases occur when the immune system attacks the body’s tissue components. Mesenchymal stem/stromal cells (MSCs) have been used as treatment to many autoimmune disorders such as type 1 diabetes,...
Published: 5/27/2026
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Inventor(s): Yufang Shi, Guangwen Ren, Liying Zhang
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
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MaxVac- Powered Toothbrush with Evacuation Technology
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Vacuum-Tooth Brush Attributes:
On-off switch, Easy-Empty (or disposable) fluid & debris collector cup, Ergonomic design, Battery-operated and Affordable.
Invention Summary:
A novel powered toothbrush that couples a vacuum suction and waste container to an existing toothbrush that automatically removes...
Published: 4/15/2026
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Inventor(s): Maxine Strickland, Vivek Kumar
Keywords(s): Cleaning/Disinfecting Products, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Dental, Technology Classifications > Consumer & Household Goods
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Chemogenetic Treatment for Neurodegenerative and Neuropsychiatric Disorders
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DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like...
Published: 2/20/2026
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Inventor(s): Gary Aston-Jones
Keywords(s):
Category(s): Technology Classifications > CNS Disorder, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
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In situ gel vehicle for ophthalmic drug delivery
Polymer compositions were screened with amplitude oscillation and show synergistic effects with simulated tear fluid
Invention Summary:
Effective ophthalmic drug delivery remains a significant challenge due to the eye’s natural defense mechanisms, including blinking, tear turnover, and nasolacrimal drainage, which rapidly clear topically...
Published: 6/5/2026
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Inventor(s): Patrick Sinko, Benjamin Yee, Dayuan Gao
Keywords(s):
Category(s): Technology Classifications > Therapeutics
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Fluorescence Polarization Probe for identifying inhibitors of Enterovirus D68 2C
Design of the 2C fluorescence polarization probe Jun14157 and assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where...
Published: 6/17/2026
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Inventor(s): Jun Wang, Kan Li, Hiwot Demssie
Keywords(s):
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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“Y”-shaped symmetric Enterovirus D68 2C inhibitors are antiviral drug candidates
Graphical abstract describing design of “Y”-shaped symmetric 2C inhibitors. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis...
Published: 2/20/2026
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Inventor(s): Jun Wang, Hiwot Demssie
Keywords(s):
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates
Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link).
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts...
Published: 2/20/2026
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav
Keywords(s):
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 2/20/2026
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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