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Tirzepatide and other GLP1RA as a novel treatment for patients with congenital generalized lipodystrophy
The image represents the mechanism of action of Tirzepatide. Image courtesy: Rabbani et al., 2024
Invention Summary:
Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder, affecting approximately 1 in 10 million...
Published: 12/5/2024
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Inventor(s): Christoph Buettner, Svetlana Ten
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Sertraline: Anti-Mycotic and Anti-Obesity Applications
Allosteric binding of sertraline with PAP results in a drastic reduction of yeast cells
Invention Summary:
Triacylglycerols are the main form of fat in the human body. Two key intermediates in triacylglycerol synthesis include phosphatidic acid and diacylglycerol....
Published: 11/20/2024
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Inventor(s): George Carman, Geordan Stukey
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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GDA Inhibitors for the Treatment of Spinal Cord-Induced Neuropathic Pain
Invention Summary:
Spinal cord injury (SCI) and its associated chronic pain can significantly diminish quality of life. While therapies like spinal cord stimulation and neuromodulation offer potential pain relief, current pharmacological options fall short, often proving ineffective, short-lived, and laden with side effects, including addiction....
Published: 11/6/2024
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Inventor(s): Bonnie Firestein-Miller, Stella Elkabes
Keywords(s): Neurological disorder & neuropathic pain, Spinal Cord
Category(s): Technology Classifications > Therapeutics, Technology Classifications > CNS Disorder, Technology Classifications > Healthcare & Life Sciences
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MYC Program as a biomarker of response to treatment with Enzalutamide
Invention Summary:
Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to...
Published: 10/11/2024
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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New Drugs for the Prevention of Kidney Stones
In vivo efficacy study of an LH prodrug expressed as days CaOx crystals were detected in mouse urine/mouse/week
Invention Summary:
Hyperoxaluria is a condition characterized by excessive urinary excretion of oxalate. It can result from inherited genetic mutations, intestinal diseases, or a diet high in oxalate. This often leads to calcium...
Published: 11/20/2024
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Inventor(s): Longqin Hu, Yiling Wang
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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CAR-NK based combinatorial treatment for
drug-resistant tumors
Incucyte Killing Assay Images with AnnexinV cell death signal in MKI-Resistant HCC (Top panel). Chromium-51 release assays comparing GRP78 CAR-NK Killing to Naïve NK killing of various MKI-resistant tumor cell lines (bottom panels). Values shown are Means ± SEM. Significant p values indicated in red.
Invention Summary:
CAR-NK...
Published: 8/19/2024
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Inventor(s): Dongfang Liu, Youssef Sabha, Chih-Hsiung Chen
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Biodegradable and Biocompatible Bioactive-based Polymers - Versatile Platform Technology
Invention Summary:
The Uhrich group has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones through labile linkages,...
Published: 11/1/2024
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Bioengineering scaffolds, Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Nutraceuticals for Preventing Leaky Gut
Image Legend: Control intestinal organoids and organoids conditioned to have a leak, or more permeable barrier, were treated with nutraceuticals which clearly prevented increased permeability in the “leaky” organoids. Similar findings were observed in cell culture and in vivo
Invention Summary:
More than 22 million Americans...
Published: 10/21/2024
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Inventor(s): Ronaldo Ferraris, Nan Gao, Wei Li
Keywords(s):
Category(s): Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Biologic inhibitors to reduce adverse effects of traditional opioids without compromising analgesia
Invention Summary:
Mu opioids, including morphine, fentanyl, and oxycodone, remain the mainstream drugs for moderate-to-severe pain management in the clinic despite their side-effects, such as tolerance, reward, addiction, and respiratory depression. However, misusing these mu opioids can magnify their side-effects and promote the development...
Published: 4/25/2024
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Inventor(s): Yingxian Pan
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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A treatment to promote skin wound healing
Treatment of wounds with TGM shows improved recovery compared to control group in a span of 10 days.
Invention Summary:
Helminths are potent modulators of immune function capable of stimulating an immune response that includes significant wound healing effector functions. Effective wound repair requires both the direct reconstruction...
Published: 7/26/2024
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Inventor(s): William Gause, Fei Chen, Zhugong Liu, Pankaj Mishra
Keywords(s): Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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