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MaxVac- Powered Toothbrush with Evacuation Technology
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Vacuum-Tooth Brush Attributes:
On-off switch, Easy-Empty (or disposable) fluid & debris collector cup, Ergonomic design, Battery-operated and Affordable.
Invention Summary:
A novel powered toothbrush that couples a vacuum suction and waste container to an existing toothbrush that automatically removes...
Published: 9/23/2025
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Inventor(s): Maxine Strickland, Vivek Kumar
Keywords(s): Cleaning/Disinfecting Products, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Dental, Technology Classifications > Consumer & Household Goods
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Chemogenetic Treatment for Neurodegenerative and Neuropsychiatric Disorders
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DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like...
Published: 10/3/2025
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Inventor(s): Gary Aston-Jones
Keywords(s):
Category(s): Technology Classifications > CNS Disorder, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
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In situ gel vehicle for ophthalmic drug delivery
Polymer compositions were screened with amplitude oscillation and show synergistic effects with simulated tear fluid
Invention Summary:
Effective ophthalmic drug delivery remains a significant challenge due to the eye’s natural defense mechanisms, including blinking, tear turnover, and nasolacrimal drainage, which rapidly clear topically...
Published: 8/28/2025
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Inventor(s): Patrick Sinko, Benjamin Yee, Dayuan Gao
Keywords(s):
Category(s): Technology Classifications > Therapeutics
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Fluorescence Polarization Probe for identifying inhibitors of Enterovirus D68 2C
Design of the 2C fluorescence polarization probe Jun14157 and assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where...
Published: 8/20/2025
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Inventor(s): Jun Wang, Kan Li
Keywords(s):
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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“Y”-shaped symmetric Enterovirus D68 2C inhibitors are antiviral drug candidates
Graphical abstract describing design of “Y”-shaped symmetric 2C inhibitors. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis...
Published: 8/20/2025
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Inventor(s): Jun Wang, Hiwot Demssie
Keywords(s):
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates
Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link).
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts...
Published: 8/8/2025
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav
Keywords(s):
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Ahmadullah Ansari, Francesc Ruiz Figueras, Edward Arnold
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
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Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Specific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia
Preliminary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study
Invention Summary:
Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 8/20/2025
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Inventor(s): Yingxian Pan
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications, Technology Classifications > Therapeutics
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