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Efficient and Non-Genotoxic Gene Transfer System for Stem Cells
Comparison of efficiency and toxicity of transfection reagents carrying different amounts of DNA for mesenchymal stem cells (MSCs). These cells are primary cells and considered hard-to-transfect. Panel A shows the transfection efficiency of “Rutgers Transfection System” in comparison to the five most widely used commercially available reagents;...
Published: 5/22/2024
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Inventor(s): Arash Hatefi, Xuguang Chen, Alireza Nomani
Keywords(s): Stem Cells, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid.
B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord
Invention Summary:
3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 9/12/2024
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Inventor(s): Ki-Bum Lee, Christopher Rathnam, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
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Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration
Invention Summary:
The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have...
Published: 9/12/2024
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy, Technology Classifications > Therapeutics
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Biodegradable Scaffold for Advanced Stem Cell Therapy
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet
Invention Summary:
While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation.
Researchers at Rutgers University...
Published: 9/12/2024
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Biomaterials, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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Stem Cell Growth Matrices with Enhanced Homogeneity, Stemness & Proliferation and Reduced Need for Feeding
Invention Summary:
There is currently no universal platform or widely accepted technique to efficiently and reproducibly grow stem and progenitor cells (SPCs) in vitro. Stem cells require contact with extracellular matrices as well as signals from growth factors to proliferate and to retain their stemness (preventing their differentiation towards progenitors)....
Published: 12/4/2024
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Inventor(s): Steven (steve) Levison, Nolan Skop, Frances Calderon, Cheul Cho, Chirag Gandhi
Keywords(s): Stem Cells, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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