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Intervertebral Disc Repair Using a 3D Porous Hybrid Protein Nanoscaffold
Histological analysis of rat intervertebral disc tissue prior to (left) and post injury (center) compared to 6 weeks post treatment (right).
Invention Summary:
Degeneration of fibrocartilaginous tissues, such as intervertebral discs (IVD), knee menisci, and other tendon-bone junctions, can lead to debilitating pain. IVD degeneration is the...
Published: 2/20/2026
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Inventor(s): Ki-Bum Lee, Letao Yang, Inbo Han
Keywords(s):
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Biomaterials
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Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
Schematic representation of MitoScript and its components
Invention Summary:
Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 2/20/2026
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s):
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues.
Invention Summary:
Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming. In nature,...
Published: 2/20/2026
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration
Invention Summary:
The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have...
Published: 2/20/2026
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy, Technology Classifications > Therapeutics
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Biodegradable Scaffold for Advanced Stem Cell Therapy
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet
Invention Summary:
While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation.
Researchers at Rutgers University...
Published: 2/20/2026
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Biomaterials, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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