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Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer
Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models.
Invention Summary:
Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...
Published: 6/24/2025
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Inventor(s): Sungyun Kim, Ki-Bum Lee, Hyun-Jong Cho
Keywords(s): Anti-cancer, Breast Cancer, Drug Delivery, Nanotechnology, Wound healing
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Systems and Methods for Detecting Acute Changes in Blood Pressure and Creating Alarm, from Photoplethysmogram
Invention Summary:
Recently, the data-driven capabilities of deep learning have been leveraged in blood pressure (BP) monitoring systems that utilize photoplethysmogram (PPG) signals. These advancements aim to enhance estimation accuracy, clinical applicability, and ultimately, patient outcomes. However, challenges persist—particularly...
Published: 6/25/2025
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Inventor(s): Laleh Najafizadeh, Weinan Wang
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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Surface Enhanced Raman Spectroscopy (SERS) based sensing platform with machine learning
Invention Summary:
Surface enhanced Raman spectroscopy (SERS) is a technique that can discriminate analyte molecules from the unique vibrational pattern they produce, which is correlated to their molecular structure. Identifying changes such as single base mutation in DNA, RNA and disease-specific microRNA biomarkers can facilitate early diagnosis...
Published: 6/10/2025
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Inventor(s): Laura Fabris, Ahmed Aziz Ezzat, Jinisha Chheda, Yating Fang
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Sensors, Technology Classifications > Software & Algorithms
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Novel Antibiotic Inhibiting Elongation Factor Complex in Gram-Positive Bacteria
Invention Summary:
Antibiotic resistance remains a global health challenge with millions of related deaths each year. Gram-positive bacterial infections, like those caused by Staphylococcus aureus, are likely to acquire and develop resistance to clinically available antibiotics. Therefore, it is crucial to identify and develop novel antibiotics...
Published: 6/5/2025
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Inventor(s): Wlodek Mandecki, Emanuel Goldman, Maxim Chudaev, Mark Henderson, Juan Marugan, Wenjuan Ye, Kenneth Wilson, Dane Parker
Keywords(s): Antibacterial, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Synthesis of Non-steroidal Anti-Inflammatory Compounds to
Promote Wound Healing
Graph shows the average skin punch biopsy weight of mice treated topically with nitrogen mustard (NM) to induce skin inflammation. Mice additionally treated with polyamine-imidazole conjugates showed a marked decrease in skin inflammation.
Invention Summary:
Non-steroidal Anti-Inflammatory drugs (NSAIDs) are widely available for over-the-counter...
Published: 5/30/2025
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Inventor(s): Jeffrey Laskin, Ned Heindel, Christophe Guillon
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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Buccal swab-based biomarkers for schizophrenia
mRNA normalized fold expression from transcript of interest
Invention Summary:
Schizophrenia (SCZ) is a debilitating and chronic brain disorder characterized by symptoms, such as hallucinations, delusions, and disorganized thoughts. Current diagnostic criteria rely solely on behavioral observations and do not account for molecular and clinical...
Published: 4/30/2025
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Inventor(s): Bonnie Firestein-Miller, Irving Vega, Steven Silverstein
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Epstein Barr Virus -specific T cells and their therapeutic use in lung cancer
Invention Summary:
Scientists from the Rutgers University and Stanford University have discovered T cell receptor molecules targeting a novel antigen upregulated in cancer. This discovery has potential value for cancer-targeting therapies, particularly CAR T therapies. Currently, a limited number of CAR T therapies indicated for a narrow range...
Published: 4/9/2025
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Inventor(s): Shin-Heng Chiou, Diane Tseng, Crystal Mackall, Mark Davis
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences
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Small molecules that target RNA structures within the CoV genome
Chemical structure of the three lead molecules derived from the focused library screen against OC43-infected Vero E6 cell screening (Zafferani et al 2021)
Invention Summary:
The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes...
Published: 7/2/2025
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Inventor(s): Amanda Hargrove, Blanton Tolbert, Gary Brewer, Neeraj Patwardhan, Mei-Ling Li
Keywords(s): Antiviral, Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Tricyclic Inhibitors of Ribosome‐Inhibiting Proteins
An image that shows p-stalk binding blockage would lead to the prevention of damage caused by Shiga or Ricin toxins
Invention Summary:
Shiga Toxin-producing E. coli (STEC) are very common bacteria that can cause infections that lead to approximately 100,000 illnesses, 3,000 hospitalizations, and about 90 deaths annually in the United States....
Published: 3/31/2025
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Inventor(s): Jacques Roberge, Xiao-Ping Li, Anastasiia Tsymbal, Nilgun Tumer
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Engineering of ATP6 for increased ATP Production
ATP synthesis assays using membranes from the indicated strains demonstrates that exAtpB exhibits faster kinetics based on luminescence measurement
Invention Summary:
Mitochondrial disease impacts thousands of children, presenting a significant health problem. Many of these conditions occur due to ATP synthase mutations; the most prevalent...
Published: 3/13/2025
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Inventor(s): Eric Klein, Truman Dunkley, Daniel Shain
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences
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