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Optogalvanic Effect Detection System
Calibration curve using the SRO
Invention Summary:
Current methods for achieving single atom counting and analysis are limited by background noise, limited precision and accuracy, long sample measurement times, and ease of use.
Researchers at Rutgers have developed an optogalvanic effect detection system for determining the composition...
Published: 2/6/2023
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Inventor(s): Daniel Murnick, Mark Deguzman, Al Dutcher
Keywords(s): Drug Discovery/Screening, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Serological/ELISA-Based Test For COVID-19
Invention Summary:
The unprecedented outbreak and spread of SARS-CoV-2 has led to rapid development of the COVID-19 pandemic. Since its beginning in 2020, the virus has rapidly evolved due to its spread, causing the generation of novel variants like Omicron more recently. Thus, there is still an unmet need for more specific, reliable, and high throughput...
Published: 2/2/2023
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Inventor(s): Maria Gennaro, Abraham Pinter
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19
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Enzyme Catalyzed Toehold Mediated Strand Displacement (TMSD)
Invention Summary:
Toehold mediated strand displacement (TMSD) is widely used in nanotechnology applications such as DNA nano-circuits and devices. The toeholds which are small single‐stranded DNA overhangs, are often utilized in kinetically controlled complex biochemical circuits. Existing toehold mediated strand displacement (TMSD)...
Published: 1/24/2023
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Inventor(s): Smita Patel, Laura Johnson, Gayatri Patel, Anupam Singh
Keywords(s): Biosensor, Catalysts, Nanotechnology
Category(s): Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences
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Nanosphere Size Control by Varying the Ratio of Copolymer Blends
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Schematic showing the process of creating drug-loaded nanospheres
Invention Summary:
Recent advances in nanotechnology have demonstrated the advantages of encapsulating poorly bioavailable drugs in nanometer-sized spheres (nanospheres) and deliver them in a targeted manner....
Published: 1/17/2023
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Inventor(s): Joachim Kohn, Mariana Reis Nogueira de Lima
Keywords(s): Biomaterials, Drug Delivery, Nanotechnology, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
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Gsx1 GENE THERAPY TO TREAT SPINAL CORD INJURY
Gsx1 treatment promotes recovery of locomotion function in injured mice.
Invention Summary:
Spinal cord injury (SCI) can lead to permanent disruption of nervous system function. There is no effective treatment for promoting recovery of motor function after SCI currently available on the market. Previous research on SCI treatment focused on...
Published: 1/11/2023
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Inventor(s): Li Cai, Misaal Patel, Lisa Lyu
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy, Technology Classifications > CNS Disorder
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Rapid Diagnostics of Tick-borne Diseases
Invention Summary:
Tick-borne diseases are a major health problem in the United States. Among them, Lyme disease due to the Borrelia spp., Anaplasmosis due to Anaplasma spp., and Babesiosis caused by Babesia spp., account for a large number of cases occurring throughout the country. Although treatment is readily available to combat these pathogens,...
Published: 1/11/2023
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Inventor(s): Nikhat Parveen, Salvatore Marras
Keywords(s): Disease Animal Models, Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Methods of diagnosing B cell malignancies and detecting B cell malignancy relapse
Workflow schematic of the diagnostic platform for detecting B cell malignancies.
Invention Summary:
B cell malignancies comprise more than 50% of blood cancers and approximately 90% of all lymphomas. Existing technologies for the detection of B cell malignancies include modern imaging technologies, flow cytometry of B cell subpopulations, cytogenetic...
Published: 1/6/2023
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Inventor(s): Ping Xie, Jaeyong Jung, Roger Strair, Samantha Gokhale
Keywords(s): Cancer biomarkers
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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DEVELOPMENT OF SPECIFIC CRK-LIKE ADAPTOR PROTEIN INHIBITORS FOR CANCER THERAPY
NC5 inhibits tumor growth and prolongs survival in vivo. NC5 treatment inhibits TNBC tumor growth and prolongs mice survival in xenograft and PDX mouse models. (A) Survival of mice bearing MDA-MB-231-Luc orthotopic xenograft tumors following treatment with vehicle (black line), Gleevec (blue line), or NC5 (red line). (B) Survival of mice bearing PDX...
Published: 1/5/2023
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Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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ADENO-ASSOCIATED VIRUS (AAV) DIRECTED ANTIOXIDATIVE GENE THERAPY FOR THE PREVENTION AND TREATMENT OF NOISE-INDUCED HEARING LOSS
Invention Summary:
Hearing loss is the third most common chronic health problem in the United States, with noise-induced hearing loss effecting nearly 1 out of every 4 adults (over 60M). Inner ear hearing damage is prevalent from recreational and occupational noise exposures, like music concerts, construction sites, factory settings, and military...
Published: 1/4/2023
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Inventor(s): P. Ashley Wackym, Todd Mowery
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences
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Techniques for Measuring Atypical Neurodevelopment in Neonates Based on Auditory Brainstem Response (ABR) Tests
Comparison of ABR signatures from neonates who showed typical (blue) or delayed and narrow, atypical (red) later diagnosed with autism spectrum disorder (ASD).
Invention Summary:
Neurodevelopmental disorders such as cerebral palsy and autism are primarily diagnosed through identification of key behaviors and symptoms. To do this, features...
Published: 1/23/2023
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Inventor(s): Elizabeth Torres, Thodoros Bermperidis
Keywords(s): Autism, Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences
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