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Bioinformatic Methods for Determining Resistance to Cancer Treatments
Invention Summary:
Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible.
Researchers at Rutgers University have...
Published: 7/15/2024
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Inventor(s): Antonina Mitrofanova, Sukanya Panja, Sarki Abdulkadir, Vishal Kothari, Edward Schaeffer
Keywords(s): Bioinformatics, Biomarkers, Digital Health, Prostate Cancer
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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Low-cost pipeline for assessing tissue remodeling and fibrosis using ultrasound
Cardiac Ultrasound Fingerprinting is an approach for high throughput extraction of myocardial features
Invention Summary:
Tissue characterization of myocardial pathology has been an area of intense research and development due to the rising incidence of cardiovascular conditions and the growing geriatric population globally. Although Cardiac Magnetic...
Published: 5/10/2024
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Inventor(s): Partho Sengupta
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Healthcare & Life Sciences
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Standardized Individual Pain Assessment Tool
A pipeline for utilizing facial, motor, and cardiac signals to measure an individual’s pain threshold
Invention Summary:
Self‐reporting of a person’s subjective level of pain is highly variable. This is due to individual differences in the way human beings experience pain. At present, no objective physiological scale of pain exists...
Published: 5/10/2024
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Inventor(s): Elizabeth Torres, Mona Elsayed
Keywords(s): Autism
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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CAR-NK based combinatorial treatment for
drug-resistant tumors
Incucyte Killing Assay Images with AnnexinV cell death signal in MKI-Resistant HCC (Top panel). Chromium-51 release assays comparing GRP78 CAR-NK Killing to Naïve NK killing of various MKI-resistant tumor cell lines (bottom panels). Values shown are Means ± SEM. Significant p values indicated in red.
Invention Summary:
CAR-NK...
Published: 7/24/2024
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Inventor(s): Dongfang Liu, Youssef Sabha, Chih-Hsiung Chen
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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IntelliGenes: AI/ML pipeline for biomarker discovery and patient diagnosis
A pipeline combining classical statistics and machine learning algorithms is used to identify disease-associated biomarkers and predict disease risk
Invention Summary:
Gene Expression Analysis and Genome‐wide association studies provide an unprecedented understanding of the genetic basis of human disease by uncovering millions of loci...
Published: 7/2/2024
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Inventor(s): Zeeshan Ahmed
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Healthcare & Life Sciences
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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19
Invention Summary:
Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical...
Published: 4/4/2024
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences
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Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19
Invention Summary:
Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for...
Published: 4/25/2024
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Inventor(s): Jeisac Guzmán Rivera, Maria Gennaro, Dirk Moore
Keywords(s): Biomarkers
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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XO-Dontia: Invisible tooth markings for increasing tooth-accuracy in dental procedures
(Left) Teeth marked with XO-Dontia under normal light exposure. (Right) The same, marked teeth when exposed to black, UV light.
Invention Summary:
Dentists use tooth numbering systems in order to mark, on referral forms and patient records, the exact teeth that must be removed via dental extractions. However, tooth numbering systems differ...
Published: 7/19/2024
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Inventor(s): Michael Conte, Nathalie Lota
Keywords(s): Polymers & Composites
Category(s): Technology Classifications > Dental, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Polymers/Composites/Materials
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A novel inhibitory mimetic peptide
slows down tumor development
Inhibitory peptide increases caspase3 activity (A) by blocking GC1/Trx1 complex thereby limiting cell proliferation by inducing cell death (B).
Invention Summary:
Soluble guanylyl cyclase (GC1) and thioredoxin 1 (Trx1), when physically interacting and attaching to each other, they acquire the ability to induce changes in other target...
Published: 7/22/2024
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Inventor(s): Annie Beuve
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Multi-Faceted Anti-inflammatory Neuroprotective Nanoparticles for Treating Alzheimer’s Disease
Invention Summary:
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and a high mortality rate in the elderly. Current therapeutic strategies fall short in halting the underlying cognitive decline and nerve cell damage. The primary features of AD are the accumulation of extracellular amyloid plaques, uncontrolled...
Published: 4/25/2024
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Inventor(s): Hoda Gebril, Prabhas Moghe, Kathryn Uhrich
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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