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Prolonged Persistance of Lacticaseibacillus rhamnosus in the Digestive Tract
Recovered CFUs from daily fecal matter after repetitive autologous murine gastrointestinal track gavages. (A) Log10 of the CFU counts from fecal matter obtained after gavage of wild type L. rhamnosus (n=2). (B) Log10 of the CFU counts from fecal matter obtained after gavage of Evolution 1, which used colonies selected from gavage 1 (n=2). (C) Log10...
Published: 9/25/2025
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Inventor(s): Biju Parekkadan, Lorenzo Tosi
Keywords(s):
Category(s): Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Healthcare & Life Sciences
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The MaxVac powered toothbrush: Suction Toothbrush and Related Methods
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Vacuum-Tooth Brush Attributes: On-off switch, Vaccum power (hi-low), Easy-Empty (or disposable) fluid & debris collector cup, Ergonomic design, Battery-operated and Affordable.
Invention Summary:
There is a need for a powered toothbrush that has a built-in...
Published: 9/23/2025
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Inventor(s): Maxine Strickland, Glennon Simmons, Dominic Peralta
Keywords(s): Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Dental, Technology Classifications, Technology Classifications > Healthcare & Life Sciences
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MaxVac- Powered Toothbrush with Evacuation Technology
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Vacuum-Tooth Brush Attributes:
On-off switch, Easy-Empty (or disposable) fluid & debris collector cup, Ergonomic design, Battery-operated and Affordable.
Invention Summary:
A novel powered toothbrush that couples a vacuum suction and waste container to an existing toothbrush that automatically removes...
Published: 9/23/2025
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Inventor(s): Maxine Strickland, Vivek Kumar
Keywords(s): Cleaning/Disinfecting Products, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Dental, Technology Classifications > Consumer & Household Goods
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Extracellular Vesicles (EVs) from Placenta and Umbilical Cord (UC) Normalize Preeclampsia (PE) Stem Cells
Z. Wang, R. Yang, J. Zhang, et al., “Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance,” Mediators of Inflammation 2021 (2021): 5558048
Invention Summary:
PE is a serious pregnancy complication affecting 5–8% of pregnancies worldwide and is a leading cause of maternal and fetal morbidity and...
Published: 9/2/2025
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Inventor(s): Lauren Sherman, Jessica Greenberg, Pranela Rameshwar, Shauna Williams
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences
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Restoration of circadian rhythms impairs formation of cancer stem cells and the growth of tumorspheres
Circadian restoration prevents tumor growth and poor prognosis
Invention Summary:
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, worsened by the presence of cancer stem cells (CSCs). These CSCs increase tumor recurrence and are responsible for tumor initiation and propagation. While conventional chemotherapy...
Published: 8/21/2025
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Inventor(s): Jean-Pierre Etchegaray, Edward Gonzalez, Dahui Wang, Maciej Jeziorek
Keywords(s):
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
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Dentin Booster
Invention Summary:
Dentin is a crucial part of our teeth, fortifying the enamel and providing protection from bacteria. Protecting the dentin layer itself from damage, such as that caused by acid and bacteria, is vital to dental hygiene. Without proper protection, tooth decay rates increase, and dentin can be slow to repair itself.
Dentin...
Published: 8/12/2025
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Inventor(s): Mohammad Ali Saghiri
Keywords(s):
Category(s): Technology Classifications > Dental, Technology Classifications > Healthcare & Life Sciences
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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Ahmadullah Ansari, Francesc Ruiz Figueras, Edward Arnold
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
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Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Specific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia
Preliminary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study
Invention Summary:
Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 8/20/2025
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Inventor(s): Yingxian Pan
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications, Technology Classifications > Therapeutics
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