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Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction
Non-covalent direct inhibition of the Keap1-Nrf2 PPI resulting in upregulation of ARE-gene expression. Thus, increase ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions.
Invention Summary:
The Keap1-Nrf2-ARE system could protect...
Published: 1/14/2025
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Inventor(s): Longqin Hu, Ahmed Ali
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Modified Simmons Catheter
Neurointerventions with improved success
Invention Summary:
The global neurovascular catheter market size was valued at USD 2.88 billion in 2020 and is expected to expand at a compound annual growth rate of 6.7% from 2021 to 2028. Neurointerventionalists, interventional radiologists, cardiologists, and vascular surgeons often can have...
Published: 1/8/2025
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Inventor(s): Amit Singla
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices
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Identification of NFAT5 as a novel target for preventing KRAS targeted therapy resistance
Inhibiting NFAT5 attenuates pancreatitis-induced resistance to KRAS inhibition and extends mouse survival.
Invention Summary:
Resistance to KRAS targeted therapy in cancers involves epithelial-to-mesenchymal transition (EMT), which poses challenges for effective targeting. However, the mechanism underlying EMT associated KRAS resistance...
Published: 1/6/2025
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Inventor(s): Pingping Hou, Daiyong Deng
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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PRISM: Precise Identification of Species of the Microbiome
Invention Summary:
The human microbiome plays a critical role in health and disease, influencing conditions such as cardiovascular disease, cancer, and autoimmune disorders. However, analysis of microbial genetics data has struggled to overcome the effects of false positive and false negative data. Computational methods are further constrained...
Published: 12/17/2024
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Inventor(s): Bassel Ghaddar, Subhajyoti De
Keywords(s):
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
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Digital tool measures movement patterns during social interaction to support autism diagnosis
Overview of the digital ADOS process, where sensors yield biometric data that are analyzed by signal processing tools in a machine learning approach to differentiate between patient type and group.
Invention Summary:
The Autism Diagnosis Observation Schedule (ADOS) is the gold standard for autism diagnosis. However, a significant number of...
Published: 12/13/2024
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Inventor(s): Elizabeth Torres, Theodoros Bermperidis
Keywords(s): Autism
Category(s): Technology Classifications > Healthcare & Life Sciences
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MYC Program as a biomarker of response to treatment with Enzalutamide
Invention Summary:
Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to...
Published: 12/12/2024
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Tirzepatide and other GLP1RA as a novel treatment for patients with congenital generalized lipodystrophy
The image represents the mechanism of action of Tirzepatide. Image courtesy: Rabbani et al., 2024
Invention Summary:
Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder, affecting approximately 1 in 10 million...
Published: 12/5/2024
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Inventor(s): Christoph Buettner, Svetlana Ten
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Three‐Dimensional, Load‐Sharing, Pre‐Vascularized
Scaffold for Bone Regeneration
Bi-weekly x-rays (A) showed progressive bone regeneration up to 10 weeks. The reconstructed CT images (B & C) show bone growing into and within the scaffold while the scaffolds maintained their mechanical strength.
Invention Summary:
Over 600,000 bone grafting procedures are performed in the US annually. While bone autografting is the gold...
Published: 12/11/2024
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Inventor(s): Joseph Freeman, Shreya Madhavarapu, Adhithi Lakshmikanthan
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Sertraline: Anti-Mycotic and Anti-Obesity Applications
Allosteric binding of sertraline with PAP results in a drastic reduction of yeast cells
Invention Summary:
Triacylglycerols are the main form of fat in the human body. Two key intermediates in triacylglycerol synthesis include phosphatidic acid and diacylglycerol....
Published: 11/20/2024
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Inventor(s): George Carman, Geordan Stukey
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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IDENTIFYING TREATMENT RESPONSE SIGNATURES
Invention Summary:
Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible.
Researchers at Rutgers University have...
Published: 11/12/2024
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Inventor(s): Antonina Mitrofanova, Sukanya Panja
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
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