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Tricyclic Inhibitors of Ribosome‐Inhibiting Proteins
An image that shows p-stalk binding blockage would lead to the prevention of damage caused by Shiga or Ricin toxins
Invention Summary:
Shiga Toxin-producing E. coli (STEC) are very common bacteria that can cause infections that lead to approximately 100,000 illnesses, 3,000 hospitalizations, and about 90 deaths annually in the United States....
Published: 3/31/2025
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Inventor(s): Jacques Roberge, Xiao-Ping Li, Anastasiia Tsymbal, Nilgun Tumer
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Engineering of ATP6 for increased ATP Production
ATP synthesis assays using membranes from the indicated strains demonstrates that exAtpB exhibits faster kinetics based on luminescence measurement
Invention Summary:
Mitochondrial disease impacts thousands of children, presenting a significant health problem. Many of these conditions occur due to ATP synthase mutations; the most prevalent...
Published: 3/13/2025
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Inventor(s): Eric Klein, Truman Dunkley, Daniel Shain
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences
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CHIR99021 Loaded Polymeric Scaffolds for the Treatment of Muscle Injuries
CHIR99021 administration reduces adipocyte differentiation (as seen by lipid droplet formation) in adipogenic cultures of stem cells. (A) Oil Red O staining for lipids 14 days after adipogenic induction. (B) Quantification of Oil Red O staining after 14 and 21 days.)
Invention Summary:
The most common injury among athletes are muscle injuries,...
Published: 3/25/2025
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Inventor(s): Doga Oruc, Joseph Freeman
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Multi‐modal composite modeling: modeling & material discovery for complex material and tissue synthesis
Invention Summary:
In 2021, there were over 200,000 traumatic brain injury (TBI) related hospitalizations and over 69,000 TBI-related deaths. Many more neurological diseases and injuries depend on research using brain tissue. Mechanical characterization of brain tissues (and other soft non-linear composites) and their computational modeling...
Published: 2/28/2025
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Inventor(s): Mohit Agarwal, Assimina Pelegri
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
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BLTP3A (also known as UHRF1BP1) silenced CAR-T cells demonstrate elevated efficacy against High-grade serous carcinoma (HGSC)
Impairing BLTP3A elevates T cells activity via enhanced recycling of TCR and CAR machinery through the endosomal system.
Invention Summary:
Despite recent advances in cancer immunotherapy, objective responses remain rare. This is partly due to an incomplete understanding of the complex immunosuppressive mechanisms operating within the...
Published: 2/21/2025
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Inventor(s): Kyle Payne, Fnu Kumari
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
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Cell-Based Biosensor for Monitoring Neuronal Stem Cell Differentiation
Movement of fluorescent cargo (EGFP, green) from the cytoplasm to the nucleus (Hoechst, blue) as early as 10 minutes after stimulation with hippocalcin
Invention Summary:
Monitoring neuronal differentiation in stem cells is vital to advance regenerative stem cell therapies and our understanding of various neurodegenerative diseases. Traditional...
Published: 2/21/2025
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Inventor(s): Ki-Bum Lee, Youngeun Kwon, Euiyeon Lee
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
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Novel FISH probes for the prognosis of malignant transformation in Barrett’s epithelium
Left: Translocations as visualized by FISH assay during metaphase. Right: Fusion as visualized in human esophageal adenocarcinoma tissue sectionInvention Summary:Barrett’s epithelium (BE) is a premalignant tissue that can progress into esophageal adenocarcinoma (EA) following the metaplasia→low grade dysplasia→ high grade dysplasia→cancer sequence....
Published: 2/12/2025
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Inventor(s): Kiron Das, Manisha Bajpai, Hana Aviv
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
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Use Of Generative AI and Impedance Cytometry for Ionic Microscopy and Cell Imaging
Invention Summary:
Traditional cell identification methods, often relying on complex microscopy or fluorescence-activated cell sorting (FACS), are time-consuming, and require expensive and bulky instruments. This highlights the need for more precise, rapid, and affordable diagnostic tools.
Rutgers researchers have developed a novel...
Published: 3/25/2025
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Inventor(s): Mehdi Javanmard, Gulam Rather, Mahtab Kokabi
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices
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Treatments for tuberculosis and non-tuberculous mycobacterial infections: dual-targeted rifamycin-AAP conjugates (RifaAAPs)
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Invention Summary:
RifaAAPs are novel dual-targeted, low-resistance-emergence, orally-available compounds for treatment of tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections--including drug-resistant, multi-drug-resistant (MDR), and extensively-drug-resistant (XDR) strains.
Researchers indicate that...
Published: 1/31/2025
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Inventor(s): Richard Ebright, Yon Ebright, Chih-Tsung Lin
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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ANTIBACTERIAL AGENTS: DUAL-TARGETED RNA POLYMERASE INHIBITORS (BENZOXAZINO-RIFAAAPS
Invention Summary:
RifaAAPs are novel dual-targeted, low-resistance-emergence, orally-available compounds for treatment of tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections--including drug-resistant, multi-drug-resistant (MDR), and extensively-drug-resistant (XDR) strains.
Researchers indicate that RifaAAPs comprise...
Published: 1/31/2025
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Inventor(s): Richard Ebright, Yon Ebright, Chih-Tsung Lin
Keywords(s): Antibacterial
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Healthcare & Life Sciences
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