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New Drugs for the Prevention of Kidney Stones
In vivo efficacy study of an LH prodrug expressed as days CaOx crystals were detected in mouse urine/mouse/week
Invention Summary:
Hyperoxaluria is a condition characterized by excessive urinary excretion of oxalate. It can result from inherited genetic mutations, intestinal diseases, or a diet high in oxalate. This often leads to calcium...
Published: 11/20/2024
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Inventor(s): Longqin Hu, Yiling Wang
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Optogalvanic Effect Detection System
Block Diagram of system
Invention Summary:
Current technologies for low specific activity radiocarbon analysis are currently limited in precision and accuracy by sample size requirements, background effects, long sample measurement times, and difficulty of use.
Researchers at Rutgers have developed an optogalvanic effect detection...
Published: 12/4/2024
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Inventor(s): Daniel Murnick, Mark Deguzman, Al Dutcher, Orlando Hernandez
Keywords(s): Drug Discovery/Screening, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Expanding Human Primary Liver Tissues into Functional Organoids
Invention Summary:
Chronic liver diseases account for approximately two million deaths per year- one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Unfortunately, there are few treatment options for these conditions, and they commonly require organ transplants. The primary...
Published: 12/16/2024
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Inventor(s): Hatim Sabaawy, Fredric Wondisford
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary:
The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 7/16/2024
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Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Human Normal and Cancer Organoid Culture with Defined Components for Six Different Tissue Types
Invention Summary:
An organoid is a small three-dimensional (3-D) cellular tissue structure that highly resembles the in-vivo organ from which it is originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from six different cancer types and normal tissues derived from patients suffering...
Published: 1/11/2024
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Inventor(s): Hatim Sabaawy, Monica Bartucci
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Novel Array Insert for One-Step 3D Cultures and Histological Processing
Schematic diagram of the technology. Organoid cultures can be grown in a basket array the size of a 96-well plate. The array can be shrunk down to fit into a histology cassette without need to transfer the culture.
Invention Summary:
Organoids are multicellular 3D structures that faithfully mimic their in vivo organ counterparts and are valuable...
Published: 12/4/2024
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Inventor(s): Hatim Sabaawy, Howon Lee, Chen Yang, Daehoon Han
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences
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In Vitro Model of Liver Steatosis for Screening of Drug Compounds
The decrease in liver steatosis in hepatocytes cultured in steatosis reducing medium.
Invention Summary:
Donor livers are frequently rejected due to high intracellular fat content, called steatosis, which increases the risk of primary graft non-function in transplant patients. Because liver transplantation remains the only effective treatment for...
Published: 10/12/2022
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Inventor(s): Martin Yarmush, Nir Nativ, Francois Berthiaume, Gabriel Yarmush, Timothy Maguire, Rene Schloss
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Novel Ricin Inhibitors
(A) Model showing the interaction of Ricin toxin A (RTA) with the P stalk to access the sarcin/ricin loop (SRL) of the eukaryotic ribosome. 26S rRNA and 60S subunit are shown in light gray and dark gray, respectively. (B) The 50% inhibitory concentration (IC50) of fragments against RTA.
Invention Summary:
Ricin toxin is lethal to human at small doses,...
Published: 12/13/2024
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Inventor(s): Nilgun Tumer, Xiao-Ping Li, Jacques Roberge, David Augeri, Bin Cao
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Fluorescent Probe for Bacterial Cell Imaging and Screening of New Antibacterial Drugs
Visualization of the impact of FtsZ-targeting drug treatment in both Gram-positive and Gram-negative bacterial strains using BOFP. Bacteria were labeled with BOFP for 5 minutes just prior to visualization. Differential interference contrast (DIC) shows unstained bacteria and fluorescence shows BOFP-labeled bacteria.
Invention Summary:
At least 2.8...
Published: 4/21/2024
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Inventor(s): Daniel Pilch, Edgar Ferrer-Gonzalez, Edmond LaVoie
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Research Tools
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Human Normal and Cancer Organoid Culture with Defined Components for Six Different Tissue Types
Invention Summary:
An organoid is a small three-dimensional (3-D) cellular tissue structure that highly resembles the in-vivo organ from which it is originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from six different cancer types and normal tissues derived from patients suffering...
Published: 11/3/2023
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Inventor(s): Hatem Sabaawy
Keywords(s): Anti-cancer, Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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