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Biomaterial-mediated Extracellular Vesicle Delivery CNS Regeneration
Reduction in cortical lesion volume post-TBI (a) and post-treatment (b); remyelination as shown by luxol fast blue-staining post-TBI (c) and post-treatment (d); and enhanced expression of occludin post treatment (f) as compared to post-TBI (e).
Invention Summary:
More than 3 billion people worldwide are affected by central nervous system...
Published: 10/3/2025
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Inventor(s): Joshua Stein, Ki-Bum Lee, Inbo Han
Keywords(s): Bioengineering scaffolds, Biomaterials, Drug Delivery, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering
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Intervertebral Disc Repair Using a 3D Porous Hybrid Protein Nanoscaffold
Histological analysis of rat intervertebral disc tissue prior to (left) and post injury (center) compared to 6 weeks post treatment (right).
Invention Summary:
Degeneration of fibrocartilaginous tissues, such as intervertebral discs (IVD), knee menisci, and other tendon-bone junctions, can lead to debilitating pain. IVD degeneration is the...
Published: 8/12/2025
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Inventor(s): Ki-Bum Lee, Letao Yang, Inbo Han
Keywords(s):
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Biomaterials
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Enhanced Intervertebral Disc Repair and Regeneration Using a Nano-Hybrid Gel
Nanomaterial (2D-Mn02)-embedded peptide hydrogel (NEPH) promotes cellular proliferation and tissue regeneration.
Invention Summary:
The limited capacity for regeneration, the presence of pro-inflammatory factors, and the complex extracellular matrix (ECM) microenvironment of degenerated intervertebral discs (IVD) remain significant issues...
Published: 8/12/2025
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Inventor(s): Ki-Bum Lee, Brian Conley, Inbo Han
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering
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Injectable Bioorthogonal Hydrogel for Intervertebral Disc Regeneration
IVD recovery imaging which demonstrates the efficacy and regeneration capability of the BIOGEL loaded with TGFB
Invention Summary:
Intervertebral disc degeneration (IVD) is the leading cause of back pain amongst humans and is a precursor to more severe conditions.
To address this issue, a team led by Rutgers scientists have developed...
Published: 10/8/2025
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Inventor(s): Ki-Bum Lee, Jeffrey Luo, Inbo Han
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering
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