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miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning.
Invention Summary:
Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024
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Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Innovative Assessment of Cardiovascular Function for Individualized Treatment, Training and Diet Plans
Invention Summary:
Measures to assess cardiovascular health range from simple tests such as blood pressure, resting heart rate, or stress test to ones that are highly invasive such as pulmonary catheterization. In patients at risk for peripheral artery disease, such as diabetics, there are other measures including reactive hyperemia tests...
Published: 12/4/2024
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Inventor(s): Andrew Gow
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Ag Biotech
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Amphiphilic Polymer Stabilized Nanoparticles with Enhanced Biological Stability and Activity
Experimental oxLDL macrophage cellular uptake results after 24-hr incubation with AM micelle or NP configurations under serum free conditions (white bars), 5% FBS (gray bars) and 20% FBS (black bars).
Invention Summary:
According to Centers for Disease Control and Prevention nearly 25% of deaths in the US is due to cardiovascular...
Published: 12/4/2024
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Inventor(s): Kathryn Uhrich, Prabhas Moghe, Adam York, Robert Prud'homme
Keywords(s): Biomaterials, Cardiovascular, Drug Delivery, Nanoparticles, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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A New Design Paradigm for Inbody Wireless Charging
Invention Summary:
Each year, millions of patients improve their quality of life through medical implants. However, the implants require batteries which need to be replaced on a regular basis through surgery, introducing extra complications, cost and risk.
Rutgers researchers have developed a system comprised of software-hardware for far-field...
Published: 3/3/2022
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Inventor(s): Richard Howard, Xiaoran Fan
Keywords(s): Cardiovascular, Electronics, Implants, Wireless
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Electronics/Semiconductor, Technology Classifications > Telecommunications & Networking, Technology Classifications > Energy & Battery
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Methods for Blood Pressure Estimation from Short Duration of Photoplethysmogram (PPG) Signals via Transfer Learning
Invention Summary:
Hypertension or high blood pressure affects a large percentage of the global adult population. Frequent self-monitoring of blood pressure (BP) is important for long-term adherence and compliance to clinical advice. However, given the intrinsic inconvenience of conventional cuff- or tonometry-based blood pressure...
Published: 4/21/2024
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Inventor(s): Laleh Najafizadeh, Weinan Wang
Keywords(s): Biosensor, Cardiovascular
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Artificial Intelligence & Machine Learning
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PulseLab: An Integrated and Expandable Toolbox for Pulse Wave Velocity-base Blood Pressure Estimation
Invention Summary:
Cuff-less blood pressure (BP) estimation methods have been long pursued as substitutions for the conventional BP measurement methods to facilitate continuous and automatic monitoring of BP. The PWV (pulse wave velocity)-BP models, describing the relationship between the PWV and the BP, have been derived and used in recent...
Published: 9/8/2022
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Inventor(s): Laleh Najafizadeh, Weinan Wang
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Research Tools, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences
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Static and Dynamic MRI Reconstruction and Segmentation
Channel-wise Attention Network Model (MICCAN)
Motion Guided Dynamic Reconstruction (MODRN)
Joint Reconstruction and Segmentation
Invention Summary:
Magnetic resonance imaging (MRI) technology is a widely used imaging technology but has several drawbacks including: the amount of time necessary for a scan, the requirement for a breath...
Published: 12/4/2024
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Inventor(s): Dimitris Metaxas, Qiaoying Huang
Keywords(s): Cardiovascular, Imaging
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Imaging, Technology Classifications > Artificial Intelligence & Machine Learning
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A Quick Estimation of Human Arterial Stiffness Using HRV
Invention Summary:
Cardiovascular diseases (CVDs) are the leading cause of deaths worldwide. Arterial elasticity is an important indicator of existing cardiovascular risks of developing CVDs. Reduced arterial elasticity or increased arterial stiffness is known to be associated with hypertension, myocardial infarction and stroke. Being able to measure...
Published: 10/21/2024
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Inventor(s): Evgeny Vaschillo, Bronya Vaschillo
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences
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Ultrasound-guided Alignment and Insertion of Percutaneous Cannulating Instruments
(Left) Device prototype. (Right) Short-axis ultrasound image of segmented vessel for insertion.
Invention Summary:
Gaining access to blood vessels is a critical first step in a plethora of diagnostic and therapeutic procedures (see market applications). The timely delivery of these interventions can affect morbidity and mortality, yet in difficult...
Published: 5/29/2024
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Inventor(s): Martin Yarmush, Alvin Chen, Max Balter, Joshua Leipheimer
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
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Drug Candidate for the Treatment of Dilated Cardiomyopathy
Invention Summary:
Dilated cardiomyopathy (DCM) is the most common cause of heart failure. About 5.7 million adults in the United States have heart failure, and approximately half million new cases are diagnosed annually. Patients with DCM can lead to arrhythmias, and about half of people who develop heart failure die within 5 years of diagnosis....
Published: 10/4/2022
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Inventor(s): Diego Fraidenraich, Qingshi Zhao
Keywords(s): Cardiovascular, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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