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Non-Feeder Cell Expansion System for Human NK and CAR-NK Cells
​ ​ Invention Summary: Current cancer treatments rely on the evolution of novel therapeutics like immunotherapies, such as the transfer and replacement of immune cells in the body. Chimeric antigen receptor (CAR) therapies are used for targeted intervention towards cancer cells, especially CAR-T cells. Innovative immunotherapies are currently...
Published: 5/10/2022   |   Inventor(s): Dongfang Liu, Xuening Wang
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cancer, Technology Classifications > Cell Therapy, Technology Classifications > Healthcare & Life Sciences
“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control. Invention Summary: COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large...
Published: 7/14/2021   |   Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
Personalized and Timed Release of Biomolecules
Invention Summary: Protein/peptide-based therapeutics are powerful medications, however their use is often hampered by very short half-lives and the necessity for intravenous or subcutaneous injections. Researchers from Rutgers University and Massachusetts General Hospital have developed a novel method to deliver protein/peptide-based therapeutics...
Published: 3/2/2020   |   Inventor(s): Biju Parekkadan, Alexandra Burr, Alfred Tamayo
Keywords(s): Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Cell Therapy, Technology Classifications > Gene Therapy
A Novel Approach for Expansion of NK and CAR-modified NK Cells
Fold expansion of NK cells from cord blood expanded with irradiated K562-mIL21 and RU-Feeder Cells Invention Summary: Chimeric antigen receptor T-cell immunotherapy (CAR-T cell therapy) requires engineering of T cells harvested from the patient. Natural killer (NK) cells are also cytotoxic immune cells, but work somewhat differently from T cell....
Published: 1/3/2020   |   Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Cell Lines
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer, Technology Classifications > Cell Therapy
Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration
Invention Summary: The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have...
Published: 8/19/2019   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy, Technology Classifications > Therapeutics
Cell Culture Scale-Up via 3D Bioactive Microcapsule
Capsules are designed to protect cells from shear, non-fouling, and customized for ease-of-use and recovery of cells. Invention Summary: Industrial cell culture scale-up is a critical unit operation in biopharmaceutical processes. Culturing adherent cells is particularly challenging, since they can’t simply be cultured in suspension but instead...
Published: 7/24/2018   |   Inventor(s): Biju Parekkadan, Ayesha Aijaz
Keywords(s):  
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy