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Atomic Scale Topological Magneto-resistance Sensor
Experimental setup for electrical transport measurement on the pyrochlore heterostructure, and STM image near the interface of EIO/DTO.
Invention Summary:
In advanced electronics and quantum technologies, there is a growing demand for materials that offer highly tunable, low-power, and robust quantum states for applications such as magnetic...
Published: 10/29/2025
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Inventor(s): Jedediah Pixley, Tsung-Chi Wu, Yueqing Chang, Jak Chakhalian, Mikhail Kareev
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Nanotechnology, Technology Classifications > Electronics/Semiconductor
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Nanoscale 3D Thermal Metrology via Scanning Electron Resistance Thermometry (SE-TherM)
(A) SEM image and (B) Temperature map of the device under test
Invention Summary:
It can be difficult to measure thermal properties at the nanoscale on operating microelectronics in a nondestructive, non-contact and real-time manner. The lack of such nanoscale thermal metrology tools affects quality control in modern microelectronics and...
Published: 10/30/2025
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Inventor(s): Amin Reihani
Keywords(s):
Category(s): Technology Classifications > Electronics/Semiconductor, Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools, Technology Classifications > Sensors
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Gold Nanocluster-Based PROTAC Targeting pTau
Gold nanocluster binds both pTau and E3 ligase, initiating the ubiquitin-proteasome pathway and degrading pTau, as seen via immunostaining (Blue – Hoechst, red – TUJ1, green – pTau)
Invention Summary:
Hyperphosphorylated tau protein, a key clinical marker for various neurodegenerative diseases, leads to abnormal aggregation...
Published: 9/12/2025
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Inventor(s): Sarah Nevins, Ki-Bum Lee
Keywords(s): Alzheimer’s, Drug Delivery, Inflammation, Nanoparticles
Category(s): Technology Classifications > Biomaterials, Technology Classifications > CNS Disorder, Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering
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Boosting Stem Cell Editing with CRISPR Nanoparticles
Invention Summary:
Gene editing in hematopoietic stem cells (HSCs) holds immense promise for curing genetic blood disorders such as sickle cell anemia and β-thalassemia. However, a major hurdle lies in the safe, efficient, and targeted delivery of CRISPR/Cas9 systems into these delicate stem cells. There is a critical need for innovative...
Published: 8/12/2025
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Inventor(s): Jinglin Fu, Jian Huang
Keywords(s):
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics
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Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer
Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models.
Invention Summary:
Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...
Published: 8/20/2025
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Inventor(s): Sungyun Kim, Ki-Bum Lee, Hyun-Jong Cho
Keywords(s): Anti-cancer, Breast Cancer, Drug Delivery, Nanotechnology, Wound healing
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Intervertebral Disc Repair Using a 3D Porous Hybrid Protein Nanoscaffold
Histological analysis of rat intervertebral disc tissue prior to (left) and post injury (center) compared to 6 weeks post treatment (right).
Invention Summary:
Degeneration of fibrocartilaginous tissues, such as intervertebral discs (IVD), knee menisci, and other tendon-bone junctions, can lead to debilitating pain. IVD degeneration is the...
Published: 8/12/2025
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Inventor(s): Ki-Bum Lee, Letao Yang, Inbo Han
Keywords(s):
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Biomaterials
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NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level
NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription.
Invention Summary:
As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating...
Published: 8/12/2025
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Inventor(s): Ki-Bum Lee, Sy-Tsong Chueng, Hyeon-Yeol Cho, Young Sup Yoon
Keywords(s): Nanoparticles
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning.
Invention Summary:
Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 8/12/2025
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Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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A Three-Buckyball Platform to Synthesize Structurally Defined Water-Soluble Metallofullerene Derivatives
Invention Summary:
Fullerenes, an allotrope of carbon, are polyhedral closed cages. Fullerenes are able to host additional atoms within their inner spheres. Fullerenes hosting electropositive metals (e.g. Sc, Gd, La), known as endohedral metallofullerenes (EMFs), are especially interesting as the encapsulated metals provide additional...
Published: 8/12/2025
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Inventor(s): Jianyuan Zhang, William Kopcha, Yue Sun, Rohin Biswas, Yanbang Li
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Imaging, Technology Classifications > Nanotechnology
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Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling
CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux
Invention Summary:
Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of...
Published: 8/12/2025
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Inventor(s): Ki-Bum Lee, Skylar Chuang
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology
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