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NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level
​ NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription. Invention Summary: As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating...
Published: 11/25/2024   |   Inventor(s): Ki-Bum Lee, Sy-Tsong Chueng, Hyeon-Yeol Cho, Young Sup Yoon
Keywords(s): Nanoparticles
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
​ Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024   |   Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
A Three-Buckyball Platform to Synthesize Structurally Defined Water-Soluble Metallofullerene Derivatives
​ Invention Summary: Fullerenes, an allotrope of carbon, are polyhedral closed cages. Fullerenes are able to host additional atoms within their inner spheres. Fullerenes hosting electropositive metals (e.g. Sc, Gd, La), known as endohedral metallofullerenes (EMFs), are especially interesting as the encapsulated metals provide additional...
Published: 11/26/2024   |   Inventor(s): Jianyuan Zhang, William Kopcha, Yue Sun, Rohin Biswas, Yanbang Li
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Imaging, Technology Classifications > Nanotechnology
Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling
CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux Invention Summary: Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of...
Published: 10/18/2024   |   Inventor(s): Skylar Chuang, Ki-Bum Lee
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology
Flame Synthesis of Carbon-Based Films on Liquid Surfaces
​ Schematic of an ethylene-air premix flame impinging on the liquid surface of a distilled water bath, producing carbon-based films on the liquid surface Invention Summary: The production of thin, carbon-based films on liquid surfaces often leaves behind MgO impurities, requires additional purification steps, and is reliant on the use of substrates,...
Published: 10/21/2024   |   Inventor(s): Stephen Tse, Chuiyuan Meng, Bernard Kear
Keywords(s):  
Category(s): Technology Classifications > Electronics/Semiconductor, Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Sensors
Multi-Faceted Anti-inflammatory Neuroprotective Nanoparticles for Treating Alzheimer’s Disease
​ Invention Summary: Alzheimer's disease (AD) is characterized by progressive neurodegeneration and a high mortality rate in the elderly. Current therapeutic strategies fall short in halting the underlying cognitive decline and nerve cell damage. The primary features of AD are the accumulation of extracellular amyloid plaques, uncontrolled...
Published: 10/21/2024   |   Inventor(s): Hoda Gebril, Prabhas Moghe, Kathryn Uhrich
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
In situ formation of 2D nanoparticles within elastomers for electromechanical sensing and flexible pressure pad
​ ​ Adding graphite and elastomer to batch mixer for in situ exfoliation Invention Summary: It has been known that a material’s electrical, mechanical, and chemical properties can be enhanced with the addition of graphene nanoparticles. Typically, the nanoparticles are created separately from the bulk material and are injected into...
Published: 6/19/2024   |   Inventor(s): Jennifer Lynch-Branzoi, Ali Ashraf, Ashiqur Rahman, Nazmul Islam
Keywords(s):  
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Polymers/Composites/Materials
Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
​ Schematic representation of MitoScript and its components Invention Summary: Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 9/12/2024   |   Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s):  
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
Repurposing Anthelmintics: Effects of Rafoxanide and Copper-Functionalized SBA-15 Carriers Against Methicillin-Resistant Staphylococcus aureus
e: table;telerik-style-name: TableNormal;border-collapse: collapse; } Invention Summary: Due to the rise in bacterial resistance to conventional antibiotics, materials that can administer antimicrobial drugs in a regulated manner more effectively are critically needed. While new antibiotic classes are created and widely used, existing,...
Published: 9/12/2024   |   Inventor(s): Maricely Ramírez-Hernández, Javiera Norambuena-Morales, Tewodros Asefa, Jeffrey Boyd
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Animal Health & Care, Technology Classifications > Biomaterials, Technology Classifications > Nanotechnology
Spatial Dopant Separation using Core-Shell Architecture For Upconversion Luminescent Enhancement in the Erbium-Doped System
Invention Summary: Upconversion nanoparticles (UCNPs) have gained increasing attention for various biomedical applications due to their high photostability, low autofluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emission intensities due to undesirable energy back-transfer. Further, the use of high-power density...
Published: 9/12/2024   |   Inventor(s): Ki-Bum Lee, Hudifah Rabie, Nicholas Pasquale
Keywords(s): Imaging, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Medical Imaging
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